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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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Nov 1999 Volume 4 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Nov 1999 Volume 4 Issue 5

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Article

Heat shock protein 70 and ATP as partners in cell homeostasis (Review).

  • Authors:
    • Y Mallouk
    • M Vayssier-Taussat
    • J V Bonventre
    • B S Polla

  • View Affiliations / Copyright

    Affiliations: Laboratoire de Physiologie Respiratoire, Groupe Hospitalier et Universitaire Cochin-Port Royal, Universite Paris V, 75014 Paris, France.
  • Pages: 463-537
    |
    Published online on: November 1, 1999
       https://doi.org/10.3892/ijmm.4.5.463
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Abstract

Heat shock proteins (HSP) are molecular chaperones, involved in many cellular functions such as protein folding, transport, maturation and degradation. Since they control the quality of newly synthesized proteins, HSP take part in cellular homeostasis. The Hsp70 family in particular exerts these functions in an adenosine triphosphate (ATP)-dependent manner. ATP is the main energy source used by cells to assume fundamental functions (respiration, proliferation, differentiation, apoptosis). Therefore, ATP levels have to be adapted to the requirements of the cells and ATP generation must constantly compensate ATP consumption. Nevertheless, under particular stress conditions, ATP levels decrease, threatening cell homeostasis and integrity. Cells have developed adaptive and protective mechanisms, among which Hsp70 synthesis and overexpression. In this review, we focus on the mechanisms which regulate Hsp70 expression under ATP depletion, using ischaemia as a paradigmatic model for ATP depletion in vivo, and analyze the molecular targets for Hsp70-mediated protection against ATP depletion. We also consider how these Hsp70-mediated protective effects could be applied in the therapeutical approaches of human diseases associated with cellular ATP depletion.

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Copy and paste a formatted citation
Spandidos Publications style
Mallouk Y, Vayssier-Taussat M, Bonventre J and Polla B: Heat shock protein 70 and ATP as partners in cell homeostasis (Review).. Int J Mol Med 4: 463-537, 1999.
APA
Mallouk, Y., Vayssier-Taussat, M., Bonventre, J., & Polla, B. (1999). Heat shock protein 70 and ATP as partners in cell homeostasis (Review).. International Journal of Molecular Medicine, 4, 463-537. https://doi.org/10.3892/ijmm.4.5.463
MLA
Mallouk, Y., Vayssier-Taussat, M., Bonventre, J., Polla, B."Heat shock protein 70 and ATP as partners in cell homeostasis (Review).". International Journal of Molecular Medicine 4.5 (1999): 463-537.
Chicago
Mallouk, Y., Vayssier-Taussat, M., Bonventre, J., Polla, B."Heat shock protein 70 and ATP as partners in cell homeostasis (Review).". International Journal of Molecular Medicine 4, no. 5 (1999): 463-537. https://doi.org/10.3892/ijmm.4.5.463
Copy and paste a formatted citation
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Spandidos Publications style
Mallouk Y, Vayssier-Taussat M, Bonventre J and Polla B: Heat shock protein 70 and ATP as partners in cell homeostasis (Review).. Int J Mol Med 4: 463-537, 1999.
APA
Mallouk, Y., Vayssier-Taussat, M., Bonventre, J., & Polla, B. (1999). Heat shock protein 70 and ATP as partners in cell homeostasis (Review).. International Journal of Molecular Medicine, 4, 463-537. https://doi.org/10.3892/ijmm.4.5.463
MLA
Mallouk, Y., Vayssier-Taussat, M., Bonventre, J., Polla, B."Heat shock protein 70 and ATP as partners in cell homeostasis (Review).". International Journal of Molecular Medicine 4.5 (1999): 463-537.
Chicago
Mallouk, Y., Vayssier-Taussat, M., Bonventre, J., Polla, B."Heat shock protein 70 and ATP as partners in cell homeostasis (Review).". International Journal of Molecular Medicine 4, no. 5 (1999): 463-537. https://doi.org/10.3892/ijmm.4.5.463
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