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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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Jan 2000 Volume 5 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Nitric oxide production by BCG-infected pleural macrophages from C57Bl/6 and DBA-2 mice.

  • Authors:
    • E Werneck-Barroso
    • A C Novaes Moura
    • P Dias Fernandes
    • E Cruz Rosas
    • J Assreuy
    • M das Gracas M O Henriques

  • View Affiliations / Copyright

    Affiliations: Thorax Diseases Institute, Federal University of Rio de Janeiro, Brazil.
  • Pages: 95-104
    |
    Published online on: January 1, 2000
       https://doi.org/10.3892/ijmm.5.1.95
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Abstract

We studied the kinetics of in vivo nitrite production in the inflammatory reaction induced by M. bovis BCG into the pleural space. Pleural macrophages harvested from C57Bl/6 mice after acute BCG infection produced high levels of nitric oxide (NO). Enhanced production was obtained upon stimulation with LPS plus IFN-gamma. In sharp contrast, macrophages from DBA-2 mice produced low levels of NO, as nitrite, at the same time interval (24 h after BCG infection), being completely refractory to further stimulation. After the third day, NO production was similar in both strains. There was a close relationship between nitrite levels in the pleural exudate in vivo and those produced by harvested macrophages in vitro. In this in vivo system, the pattern of NO production by pleural macrophages one day after BCG infection was discrepant and unexpected in the response of C57Bl/6 and DBA-2 mice. However, this early response did not affect the late progressive NO production in both mice strains, that may be responsible to the late control of the mycobacteria growth.

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Copy and paste a formatted citation
Spandidos Publications style
Werneck-Barroso E, Novaes Moura A, Dias Fernandes P, Cruz Rosas E, Assreuy J and das Gracas M O Henriques M: Nitric oxide production by BCG-infected pleural macrophages from C57Bl/6 and DBA-2 mice.. Int J Mol Med 5: 95-104, 2000.
APA
Werneck-Barroso, E., Novaes Moura, A., Dias Fernandes, P., Cruz Rosas, E., Assreuy, J., & das Gracas M O Henriques, M. (2000). Nitric oxide production by BCG-infected pleural macrophages from C57Bl/6 and DBA-2 mice.. International Journal of Molecular Medicine, 5, 95-104. https://doi.org/10.3892/ijmm.5.1.95
MLA
Werneck-Barroso, E., Novaes Moura, A., Dias Fernandes, P., Cruz Rosas, E., Assreuy, J., das Gracas M O Henriques, M."Nitric oxide production by BCG-infected pleural macrophages from C57Bl/6 and DBA-2 mice.". International Journal of Molecular Medicine 5.1 (2000): 95-104.
Chicago
Werneck-Barroso, E., Novaes Moura, A., Dias Fernandes, P., Cruz Rosas, E., Assreuy, J., das Gracas M O Henriques, M."Nitric oxide production by BCG-infected pleural macrophages from C57Bl/6 and DBA-2 mice.". International Journal of Molecular Medicine 5, no. 1 (2000): 95-104. https://doi.org/10.3892/ijmm.5.1.95
Copy and paste a formatted citation
x
Spandidos Publications style
Werneck-Barroso E, Novaes Moura A, Dias Fernandes P, Cruz Rosas E, Assreuy J and das Gracas M O Henriques M: Nitric oxide production by BCG-infected pleural macrophages from C57Bl/6 and DBA-2 mice.. Int J Mol Med 5: 95-104, 2000.
APA
Werneck-Barroso, E., Novaes Moura, A., Dias Fernandes, P., Cruz Rosas, E., Assreuy, J., & das Gracas M O Henriques, M. (2000). Nitric oxide production by BCG-infected pleural macrophages from C57Bl/6 and DBA-2 mice.. International Journal of Molecular Medicine, 5, 95-104. https://doi.org/10.3892/ijmm.5.1.95
MLA
Werneck-Barroso, E., Novaes Moura, A., Dias Fernandes, P., Cruz Rosas, E., Assreuy, J., das Gracas M O Henriques, M."Nitric oxide production by BCG-infected pleural macrophages from C57Bl/6 and DBA-2 mice.". International Journal of Molecular Medicine 5.1 (2000): 95-104.
Chicago
Werneck-Barroso, E., Novaes Moura, A., Dias Fernandes, P., Cruz Rosas, E., Assreuy, J., das Gracas M O Henriques, M."Nitric oxide production by BCG-infected pleural macrophages from C57Bl/6 and DBA-2 mice.". International Journal of Molecular Medicine 5, no. 1 (2000): 95-104. https://doi.org/10.3892/ijmm.5.1.95
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