RNA-protein interactions in the control of stability and localization of messenger RNA (review).

  • Authors:
    • M Derrigo
    • A Cestelli
    • G Savettieri
    • I Di Liegro
  • View Affiliations

  • Published online on: February 1, 2000     https://doi.org/10.3892/ijmm.5.2.111
  • Pages: 111-134
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Growing evidence demonstrates the importance of regulating mRNA localization, stability and translation, in the control of gene expression, both in development and in differentiated cells. The signals responsible for specific regulation of mRNA metabolism reside in the RNA message itself: both 5' and 3' to the coding region, all transcripts contain variable lengths of untranslated sequences (5'-UTR and 3'-UTR) which contain the binding sites for a number of RNA-binding proteins (RBPs). Most RBPs assemble on the message at the moment of transcription, thus determining the future fate of the transcript from the very beginning. We discuss possible mechanisms through which mRNA, leaving from the nucleus as an RNA-protein complex, might reach its final intracellular destinations and how its access to the translational apparatus might be regulated in time and space. We also focus on a few known examples of aberrant RNA-protein interactions associated with human diseases, including cancer.

Related Articles

Journal Cover

Feb 2000
Volume 5 Issue 2

Print ISSN: 1107-3756
Online ISSN:1791-244X

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Derrigo M, Cestelli A, Savettieri G and Di Liegro I: RNA-protein interactions in the control of stability and localization of messenger RNA (review).. Int J Mol Med 5: 111-134, 2000.
APA
Derrigo, M., Cestelli, A., Savettieri, G., & Di Liegro, I. (2000). RNA-protein interactions in the control of stability and localization of messenger RNA (review).. International Journal of Molecular Medicine, 5, 111-134. https://doi.org/10.3892/ijmm.5.2.111
MLA
Derrigo, M., Cestelli, A., Savettieri, G., Di Liegro, I."RNA-protein interactions in the control of stability and localization of messenger RNA (review).". International Journal of Molecular Medicine 5.2 (2000): 111-134.
Chicago
Derrigo, M., Cestelli, A., Savettieri, G., Di Liegro, I."RNA-protein interactions in the control of stability and localization of messenger RNA (review).". International Journal of Molecular Medicine 5, no. 2 (2000): 111-134. https://doi.org/10.3892/ijmm.5.2.111