Vascularization is decreased in pulmonary adenocarcinoma expressing brain-specific angiogenesis inhibitor 1 (BAI1).

  • Authors:
    • H Hatanaka
    • Y Oshika
    • Y Abe
    • Y Yoshida
    • T Hashimoto
    • A Handa
    • H Kijima
    • H Yamazaki
    • H Inoue
    • Y Ueyama
    • M Nakamura
  • View Affiliations

  • Published online on: February 1, 2000     https://doi.org/10.3892/ijmm.5.2.181
  • Pages: 181-184
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Brain-specific angiogenesis inhibitor 1 (BAI1) is a novel angioinhibitory factor. We examined BAI1 gene expression in 48 pulmonary adenocarcinoma specimens by RT-PCR. Vascular density (number and measurement area) was immunohistochemically evaluated in tumor specimens using anti-CD34 monoclonal antibody. BAI1 gene expression was detected in 38 of 48 pulmonary adenocarcinomas (79. 2%). Vascular number and measurement area were significantly decreased in the BAI1-positive pulmonary adenocarcinomas (19.3+/-4. 4/microm2 and 1.7+/-0.6%) as compared with those in the BAI1-negative carcinomas (75.5+/-42.7/microm2 and 5.5+/-1.5%) (Mann-Whitney U-test, p=0.0017). These results suggest that BAI1 expression may inhibit stromal vascularization in pulmonary adenocarcinoma.

Related Articles

Journal Cover

Feb 2000
Volume 5 Issue 2

Print ISSN: 1107-3756
Online ISSN:1791-244X

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Hatanaka H, Oshika Y, Abe Y, Yoshida Y, Hashimoto T, Handa A, Kijima H, Yamazaki H, Inoue H, Ueyama Y, Ueyama Y, et al: Vascularization is decreased in pulmonary adenocarcinoma expressing brain-specific angiogenesis inhibitor 1 (BAI1).. Int J Mol Med 5: 181-184, 2000
APA
Hatanaka, H., Oshika, Y., Abe, Y., Yoshida, Y., Hashimoto, T., Handa, A. ... Nakamura, M. (2000). Vascularization is decreased in pulmonary adenocarcinoma expressing brain-specific angiogenesis inhibitor 1 (BAI1).. International Journal of Molecular Medicine, 5, 181-184. https://doi.org/10.3892/ijmm.5.2.181
MLA
Hatanaka, H., Oshika, Y., Abe, Y., Yoshida, Y., Hashimoto, T., Handa, A., Kijima, H., Yamazaki, H., Inoue, H., Ueyama, Y., Nakamura, M."Vascularization is decreased in pulmonary adenocarcinoma expressing brain-specific angiogenesis inhibitor 1 (BAI1).". International Journal of Molecular Medicine 5.2 (2000): 181-184.
Chicago
Hatanaka, H., Oshika, Y., Abe, Y., Yoshida, Y., Hashimoto, T., Handa, A., Kijima, H., Yamazaki, H., Inoue, H., Ueyama, Y., Nakamura, M."Vascularization is decreased in pulmonary adenocarcinoma expressing brain-specific angiogenesis inhibitor 1 (BAI1).". International Journal of Molecular Medicine 5, no. 2 (2000): 181-184. https://doi.org/10.3892/ijmm.5.2.181