Signaling pathways induced by vascular endothelial growth factor (review).

Larrivée,B; Karsan,A

doi:10.3892/ijmm.5.5.447

May 2000 Volume 5 Issue 5

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May 2000 Volume 5 Issue 5

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Article

Signaling pathways induced by vascular endothelial growth factor (review).

Authors:
- B Larrivée
- A Karsan
View Affiliations / Copyright

Affiliations: Department of Experimental Medicine, University of British Columbia and St. Paul's Hospital, Vancouver, British Columbia, Canada.
Pages: 447-503
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Published online on: May 1, 2000

https://doi.org/10.3892/ijmm.5.5.447
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Abstract

Vasculogenesis and angiogenesis are the mechanisms responsible for the development of the blood vessels. Angiogenesis refers to the formation of capillaries from pre-existing vessels in the embryo and adult organism, while vasculogenesis is the development of new blood vessels from the differentiation of endothelial precursors (angioblasts) in situ. Vascular endothelial growth factor (VEGF) family members are major mediators of vasculogenesis and angiogenesis both during development and in pathological conditions. VEGF has a variety of effects on vascular endothelium, including the ability to promote endothelial cell viability, mitogenesis, chemotaxis, and vascular permeability. It mediates its activity mainly via two tyrosine kinase receptors, VEGFR-1 (flt-1) and VEGFR-2 (flk-1/KDR), although other receptors, such as neuropilin-1 and -2, can also bind VEGF. Another tyrosine kinase receptor, VEGFR-3 (flt-4) binds VEGF-C and VEGF-D and is more important in the development of lymphatic vessels. While the functional effects of VEGF on endothelial cells has been well studied, not as much is known about VEGF signaling. This review summarizes the different pathways known to be involved in VEGF signal transduction and the biological responses triggered by the VEGF signaling cascade.

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Signaling pathways induced by vascular endothelial growth factor (review).

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Abstract

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