Fate of 6-deoxy-6-[123I]iodo-D-glucose in normal and diabetic rats.

  • Authors:
    • W J Malaisse
    • F Malaisse-Lagae
    • L Ladriere
    • A Schoutens
  • View Affiliations

  • Published online on: July 1, 2000     https://doi.org/10.3892/ijmm.6.1.65
  • Pages: 65-73
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Abstract

The D-glucose analog 6-deoxy-6-¿123Iĭodo-D-glucose (6-DIG) was recently proposed as a potential tracer for the in vivo characterization of D-glucose transport in distinct cell types. In this study, the validity of such a proposal was investigated in both control and streptozotocin-induced diabetic rats. 6-DIG was injected intravenously in either control or diabetic rats. The fate of 6-DIG was assessed by scintigraphy of the injected animals, blood and urine sampling, and measurement of tissue radioactivity at the time of sacrifice, 140 min after 6-DIG injection. The half-life for 6-DIG in plasma and its accumulation in kidney and urinary bladder indicated that it was mainly eliminated from the body by glomerular filtration. The urinary elimination of 6-DIG was accelerated, however, in the polyuric diabetic rats. Bile formation also apparently contributed to the clearance of 6-DIG. Its uptake by liver, heart and muscles yielded values lower than blood concentration. The usefulness of 6-DIG as a tracer for D-glucose transport in selected organs in the perspective of clinical application, e.g. by single photon emission computed tomography, requires further investigations.

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Jul 2000
Volume 6 Issue 1

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Malaisse W, Malaisse-Lagae F, Ladriere L and Schoutens A: Fate of 6-deoxy-6-[123I]iodo-D-glucose in normal and diabetic rats.. Int J Mol Med 6: 65-73, 2000
APA
Malaisse, W., Malaisse-Lagae, F., Ladriere, L., & Schoutens, A. (2000). Fate of 6-deoxy-6-[123I]iodo-D-glucose in normal and diabetic rats.. International Journal of Molecular Medicine, 6, 65-73. https://doi.org/10.3892/ijmm.6.1.65
MLA
Malaisse, W., Malaisse-Lagae, F., Ladriere, L., Schoutens, A."Fate of 6-deoxy-6-[123I]iodo-D-glucose in normal and diabetic rats.". International Journal of Molecular Medicine 6.1 (2000): 65-73.
Chicago
Malaisse, W., Malaisse-Lagae, F., Ladriere, L., Schoutens, A."Fate of 6-deoxy-6-[123I]iodo-D-glucose in normal and diabetic rats.". International Journal of Molecular Medicine 6, no. 1 (2000): 65-73. https://doi.org/10.3892/ijmm.6.1.65