AZT inhibition of the ADP/ATP antiport in isolated rat heart mitochondria.

  • Authors:
    • D Valenti
    • M Barile
    • S Passarella
  • View Affiliations

  • Published online on: July 1, 2000     https://doi.org/10.3892/ijmm.6.1.93
  • Pages: 93-99
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Abstract

In order to gain insight into the mechanism by which AZT affects mitochondrial metabolism in heart, leading to the ATP deficiency syndrome, the capability of AZT to affect certain mitochondrial translocators was checked in coupled mitochondria isolated from rat heart. AZT was found to strongly inhibit the ADP/ATP antiport, in a competitive manner (Ki 7 microM), as photometrically measured. Contrarily, the rate of the succinate/malate exchange via the dicarboxylate carrier, of the oxaloacetate uptake via the oxodicarboxylate carrier and of cis-aconitate uptake via the tricarboxylate carrier was found to be unchanged in the presence of AZT.

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Jul 2000
Volume 6 Issue 1

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Valenti D, Barile M and Passarella S: AZT inhibition of the ADP/ATP antiport in isolated rat heart mitochondria.. Int J Mol Med 6: 93-99, 2000
APA
Valenti, D., Barile, M., & Passarella, S. (2000). AZT inhibition of the ADP/ATP antiport in isolated rat heart mitochondria.. International Journal of Molecular Medicine, 6, 93-99. https://doi.org/10.3892/ijmm.6.1.93
MLA
Valenti, D., Barile, M., Passarella, S."AZT inhibition of the ADP/ATP antiport in isolated rat heart mitochondria.". International Journal of Molecular Medicine 6.1 (2000): 93-99.
Chicago
Valenti, D., Barile, M., Passarella, S."AZT inhibition of the ADP/ATP antiport in isolated rat heart mitochondria.". International Journal of Molecular Medicine 6, no. 1 (2000): 93-99. https://doi.org/10.3892/ijmm.6.1.93