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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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Aug 2000 Volume 6 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Aug 2000 Volume 6 Issue 2

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Article

Progesterone inhibits inducible nitric oxide synthase mRNA expression in human intestinal epithelial cells.

  • Authors:
    • A L Salzman
    • S C Linn
    • C Szabo

  • View Affiliations / Copyright

    Affiliations: Inotek Corporation, Beverly, MA 01915, USA.
  • Pages: 209-225
    |
    Published online on: August 1, 2000
       https://doi.org/10.3892/ijmm.6.2.209
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Abstract

Progesterone inhibits the transcription of inducible nitric oxide (NO) synthase (iNOS) in murine macrophages. The effect of female sex steroids on the regulation of the human iNOS gene, which shares no identity in the 5' and 3' non-coding regions with its murine homolog, is unknown. Pretreatment of the human enterocytic cells DLD-1 and Caco-2BBe with estradiol or dexamethasone had no effect on NO production induced by IL-1beta, LPS, and IFN-gamma. In contrast, NO production was inhibited by progesterone when administered as a pre-treatment or as a post-treatment 6 h after cytokine exposure (IC50 in DLD-1 and Caco-2BBe cells = 66 and 45 microM). Progesterone pre-treatment inhibited cytokine-induced iNOS mRNA expression by 66% and 58% in DLD-1 and Caco-2BBe cells, respectively. Nuclear run-on analysis demonstrated that progesterone did not inhibit cytokine-induced iNOS transcription. These data imply that progesterone inhibits iNOS mRNA expression at a post-transcriptional level, which is the dominant mode of iNOS regulation in human enterocytes. Since iNOS-derived NO production has been related to the inflammatory and tumorigenic response of progesterone-receptor bearing tissues, the repression of iNOS mRNA expression by a female sex steroid could play an important role in the regulation of a broad range of physiologic processes.

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Copy and paste a formatted citation
Spandidos Publications style
Salzman A, Linn S and Szabo C: Progesterone inhibits inducible nitric oxide synthase mRNA expression in human intestinal epithelial cells.. Int J Mol Med 6: 209-225, 2000.
APA
Salzman, A., Linn, S., & Szabo, C. (2000). Progesterone inhibits inducible nitric oxide synthase mRNA expression in human intestinal epithelial cells.. International Journal of Molecular Medicine, 6, 209-225. https://doi.org/10.3892/ijmm.6.2.209
MLA
Salzman, A., Linn, S., Szabo, C."Progesterone inhibits inducible nitric oxide synthase mRNA expression in human intestinal epithelial cells.". International Journal of Molecular Medicine 6.2 (2000): 209-225.
Chicago
Salzman, A., Linn, S., Szabo, C."Progesterone inhibits inducible nitric oxide synthase mRNA expression in human intestinal epithelial cells.". International Journal of Molecular Medicine 6, no. 2 (2000): 209-225. https://doi.org/10.3892/ijmm.6.2.209
Copy and paste a formatted citation
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Spandidos Publications style
Salzman A, Linn S and Szabo C: Progesterone inhibits inducible nitric oxide synthase mRNA expression in human intestinal epithelial cells.. Int J Mol Med 6: 209-225, 2000.
APA
Salzman, A., Linn, S., & Szabo, C. (2000). Progesterone inhibits inducible nitric oxide synthase mRNA expression in human intestinal epithelial cells.. International Journal of Molecular Medicine, 6, 209-225. https://doi.org/10.3892/ijmm.6.2.209
MLA
Salzman, A., Linn, S., Szabo, C."Progesterone inhibits inducible nitric oxide synthase mRNA expression in human intestinal epithelial cells.". International Journal of Molecular Medicine 6.2 (2000): 209-225.
Chicago
Salzman, A., Linn, S., Szabo, C."Progesterone inhibits inducible nitric oxide synthase mRNA expression in human intestinal epithelial cells.". International Journal of Molecular Medicine 6, no. 2 (2000): 209-225. https://doi.org/10.3892/ijmm.6.2.209
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