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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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Oct 2000 Volume 6 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Induction of NADPH:quinone oxidoreductase in murine hepatoma cells by methylsulfinyl isothiocyanates: methyl chain length-activity study.

  • Authors:
    • D X Hou
    • M Fukuda
    • M Fujii
    • Y Fuke
  • View Affiliations / Copyright

    Affiliations: Department of Biochemical Science and Technology, Faculty of Agriculture, Kagoshima University, Kagoshima 890-0065, Japan. hou@chem.agri.kagoshima-u.ac.jp
  • Pages: 441-445
    |
    Published online on: October 1, 2000
       https://doi.org/10.3892/ijmm.6.4.441
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Abstract

Methylsulfinyl isothiocyanates (MITC) are a class of isothiocyanates occurring in a variety of cruciferous vegetables showing anticarcinogenic activity. To develop analogues of methylsulfinyl isothiocyanate with less toxicity and better biological activity, four types of methyl chain length (designated as 2-, 4-, 6- and 8-MITC) were synthesized. The murine hepatoma cells (Hepa 1c1c7) were treated with various concentrations of MITC, and then assessed for cell growth, enzyme activity and mRNA expression of the detoxifying enzyme NADPH:quinone oxidoreductase (QR). All of four MITC augmented the induction of QR activity and the expression of QR mRNA in a dose-dependent manner. In the non-toxic concentration range, an increase in the methyl chain length resulted in a higher QR induction in both activity and mRNA expression. However, increasing cytotoxicity was also observed by an increase in the methyl chain length. Our results suggested that 4- and 6-MITC as QR inducers appeared to be less toxic and even more potent.

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Copy and paste a formatted citation
Spandidos Publications style
Hou D, Fukuda M, Fujii M and Fuke Y: Induction of NADPH:quinone oxidoreductase in murine hepatoma cells by methylsulfinyl isothiocyanates: methyl chain length-activity study.. Int J Mol Med 6: 441-445, 2000.
APA
Hou, D., Fukuda, M., Fujii, M., & Fuke, Y. (2000). Induction of NADPH:quinone oxidoreductase in murine hepatoma cells by methylsulfinyl isothiocyanates: methyl chain length-activity study.. International Journal of Molecular Medicine, 6, 441-445. https://doi.org/10.3892/ijmm.6.4.441
MLA
Hou, D., Fukuda, M., Fujii, M., Fuke, Y."Induction of NADPH:quinone oxidoreductase in murine hepatoma cells by methylsulfinyl isothiocyanates: methyl chain length-activity study.". International Journal of Molecular Medicine 6.4 (2000): 441-445.
Chicago
Hou, D., Fukuda, M., Fujii, M., Fuke, Y."Induction of NADPH:quinone oxidoreductase in murine hepatoma cells by methylsulfinyl isothiocyanates: methyl chain length-activity study.". International Journal of Molecular Medicine 6, no. 4 (2000): 441-445. https://doi.org/10.3892/ijmm.6.4.441
Copy and paste a formatted citation
x
Spandidos Publications style
Hou D, Fukuda M, Fujii M and Fuke Y: Induction of NADPH:quinone oxidoreductase in murine hepatoma cells by methylsulfinyl isothiocyanates: methyl chain length-activity study.. Int J Mol Med 6: 441-445, 2000.
APA
Hou, D., Fukuda, M., Fujii, M., & Fuke, Y. (2000). Induction of NADPH:quinone oxidoreductase in murine hepatoma cells by methylsulfinyl isothiocyanates: methyl chain length-activity study.. International Journal of Molecular Medicine, 6, 441-445. https://doi.org/10.3892/ijmm.6.4.441
MLA
Hou, D., Fukuda, M., Fujii, M., Fuke, Y."Induction of NADPH:quinone oxidoreductase in murine hepatoma cells by methylsulfinyl isothiocyanates: methyl chain length-activity study.". International Journal of Molecular Medicine 6.4 (2000): 441-445.
Chicago
Hou, D., Fukuda, M., Fujii, M., Fuke, Y."Induction of NADPH:quinone oxidoreductase in murine hepatoma cells by methylsulfinyl isothiocyanates: methyl chain length-activity study.". International Journal of Molecular Medicine 6, no. 4 (2000): 441-445. https://doi.org/10.3892/ijmm.6.4.441
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