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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
Journal Cover
Oct 2000 Volume 6 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Oct 2000 Volume 6 Issue 4

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Article

Comparative studies of cadmium-induced single strand breaks in female and male rats and the ameliorative effect of selenium.

  • Authors:
    • L W Forrester
    • L M Latinwo
    • C Fasanya-Odewumi
    • C Ikediobi
    • M D Abazinge
    • O Mbuya
    • J Nwoga

  • View Affiliations / Copyright

    Affiliations: Environmental Sciences Institute, Florida A & M University, Tallahassee, Fl 32307, USA.
  • Pages: 449-501
    |
    Published online on: October 1, 2000
       https://doi.org/10.3892/ijmm.6.4.449
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Abstract

Cadmium (Cd2+) is an environmental pollutant. In humans and animals it has no known biological benefit, but rather has genotoxic and carcinogenic effects. Comparative studies of cadmium-induced DNA single strand breaks in kidney and liver cells of female and male Harlan Sprague-Dawley rats were conducted, and the role of selenium in mitigating cadmium toxicity in male and female rats was also evaluated. Analysis of the results showed differences in organ and sex susceptibility to cadmium-induced DNA damage. There were more single strand breaks in DNA from liver and kidney cells of male rats than in those of the females. Concurrent administration of selenium with cadmium significantly (P<0.001) reduced DNA damage in male rats more than in female rats. However, administration of selenium alone induced DNA strand breaks in female rats at a rate which was significantly greater (P<0.001) than in male rats. These findings demonstrate differences in sex susceptibility to cadmium, and some variance in the ameliorative effects of selenium in male and female rats.

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Copy and paste a formatted citation
Spandidos Publications style
Forrester L, Latinwo L, Fasanya-Odewumi C, Ikediobi C, Abazinge M, Mbuya O and Nwoga J: Comparative studies of cadmium-induced single strand breaks in female and male rats and the ameliorative effect of selenium.. Int J Mol Med 6: 449-501, 2000.
APA
Forrester, L., Latinwo, L., Fasanya-Odewumi, C., Ikediobi, C., Abazinge, M., Mbuya, O., & Nwoga, J. (2000). Comparative studies of cadmium-induced single strand breaks in female and male rats and the ameliorative effect of selenium.. International Journal of Molecular Medicine, 6, 449-501. https://doi.org/10.3892/ijmm.6.4.449
MLA
Forrester, L., Latinwo, L., Fasanya-Odewumi, C., Ikediobi, C., Abazinge, M., Mbuya, O., Nwoga, J."Comparative studies of cadmium-induced single strand breaks in female and male rats and the ameliorative effect of selenium.". International Journal of Molecular Medicine 6.4 (2000): 449-501.
Chicago
Forrester, L., Latinwo, L., Fasanya-Odewumi, C., Ikediobi, C., Abazinge, M., Mbuya, O., Nwoga, J."Comparative studies of cadmium-induced single strand breaks in female and male rats and the ameliorative effect of selenium.". International Journal of Molecular Medicine 6, no. 4 (2000): 449-501. https://doi.org/10.3892/ijmm.6.4.449
Copy and paste a formatted citation
x
Spandidos Publications style
Forrester L, Latinwo L, Fasanya-Odewumi C, Ikediobi C, Abazinge M, Mbuya O and Nwoga J: Comparative studies of cadmium-induced single strand breaks in female and male rats and the ameliorative effect of selenium.. Int J Mol Med 6: 449-501, 2000.
APA
Forrester, L., Latinwo, L., Fasanya-Odewumi, C., Ikediobi, C., Abazinge, M., Mbuya, O., & Nwoga, J. (2000). Comparative studies of cadmium-induced single strand breaks in female and male rats and the ameliorative effect of selenium.. International Journal of Molecular Medicine, 6, 449-501. https://doi.org/10.3892/ijmm.6.4.449
MLA
Forrester, L., Latinwo, L., Fasanya-Odewumi, C., Ikediobi, C., Abazinge, M., Mbuya, O., Nwoga, J."Comparative studies of cadmium-induced single strand breaks in female and male rats and the ameliorative effect of selenium.". International Journal of Molecular Medicine 6.4 (2000): 449-501.
Chicago
Forrester, L., Latinwo, L., Fasanya-Odewumi, C., Ikediobi, C., Abazinge, M., Mbuya, O., Nwoga, J."Comparative studies of cadmium-induced single strand breaks in female and male rats and the ameliorative effect of selenium.". International Journal of Molecular Medicine 6, no. 4 (2000): 449-501. https://doi.org/10.3892/ijmm.6.4.449
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