Minimal effect of cytokine-independent hepatitis induced by anti-Fas antibodies on hepatic cytochrome P450 gene expression in mice.

  • Authors:
    • T Okamoto
    • S Okabe
  • View Affiliations

  • Published online on: October 1, 2000     https://doi.org/10.3892/ijmm.6.4.459
  • Pages: 459-521
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Abstract

The effect of cytokine-independent hepatitis on cytochrome P450 (CYP) gene expression remains unknown. Treatment of mice with anti-Fas antibodies (150 microg/kg, i.v.) caused elevated plasma alanine aminotransferase activity at 4 and 24 h after treatment. Under normal reverse-transcription polymerase chain reaction (RT-PCR) amplification conditions, no effect of anti-Fas antibody-induced hepatitis on hepatic CYP 2E1 and 3A gene expression was observed. But lower cycle RT-PCR amplification revealed slight suppression of hepatic CYP 2E1 gene expression. The present results showed that cytokine-independent hepatitis induced by anti-Fas anti-bodies had only a minimal effect on the suppression of CYP gene expression in the liver.

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Oct 2000
Volume 6 Issue 4

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Okamoto T and Okamoto T: Minimal effect of cytokine-independent hepatitis induced by anti-Fas antibodies on hepatic cytochrome P450 gene expression in mice.. Int J Mol Med 6: 459-521, 2000
APA
Okamoto, T., & Okamoto, T. (2000). Minimal effect of cytokine-independent hepatitis induced by anti-Fas antibodies on hepatic cytochrome P450 gene expression in mice.. International Journal of Molecular Medicine, 6, 459-521. https://doi.org/10.3892/ijmm.6.4.459
MLA
Okamoto, T., Okabe, S."Minimal effect of cytokine-independent hepatitis induced by anti-Fas antibodies on hepatic cytochrome P450 gene expression in mice.". International Journal of Molecular Medicine 6.4 (2000): 459-521.
Chicago
Okamoto, T., Okabe, S."Minimal effect of cytokine-independent hepatitis induced by anti-Fas antibodies on hepatic cytochrome P450 gene expression in mice.". International Journal of Molecular Medicine 6, no. 4 (2000): 459-521. https://doi.org/10.3892/ijmm.6.4.459