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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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Nov 2000 Volume 6 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
Nov 2000 Volume 6 Issue 5

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Article

Regulation of tumor cell apoptotic sensitivity during the cell cycle (Review).

  • Authors:
    • D M Smith
    • G Gao
    • X Zhang
    • G Wang
    • Q P Dou

  • View Affiliations / Copyright

    Affiliations: Drug Discovery Program, H. Lee Moffitt Cancer Center & Research Institute, Department of Biochemistry & Molecular Biology, College of Medicine, University of South Florida, Tampa, FL 33612, USA.
  • Pages: 503-510
    |
    Published online on: November 1, 2000
       https://doi.org/10.3892/ijmm.6.5.503
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Abstract

Understanding how current chemotherapeutic modalities induce apoptosis is critical to designing better anti-cancer agents. This review is concerned with how pharmacological agents induce tumor cell apoptosis in a cell cycle-dependent manner. Recent experiments demonstrate that expression of several apoptotic regulatory proteins (such as Bcl-2, Bax, p53, and Survivin) are differentially regulated according to the phases of the cell cycle. This cell cycle-dependent regulation in turn contributes to increased drug sensitivity in different phases of the cell cycle. It is therefore likely that the cell cycle-dependent expression of cell death proteins plays a role in regulating chemosensitivity and apoptotic commitment of human tumor cells.

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Copy and paste a formatted citation
Spandidos Publications style
Smith D, Gao G, Zhang X, Wang G and Dou Q: Regulation of tumor cell apoptotic sensitivity during the cell cycle (Review).. Int J Mol Med 6: 503-510, 2000.
APA
Smith, D., Gao, G., Zhang, X., Wang, G., & Dou, Q. (2000). Regulation of tumor cell apoptotic sensitivity during the cell cycle (Review).. International Journal of Molecular Medicine, 6, 503-510. https://doi.org/10.3892/ijmm.6.5.503
MLA
Smith, D., Gao, G., Zhang, X., Wang, G., Dou, Q."Regulation of tumor cell apoptotic sensitivity during the cell cycle (Review).". International Journal of Molecular Medicine 6.5 (2000): 503-510.
Chicago
Smith, D., Gao, G., Zhang, X., Wang, G., Dou, Q."Regulation of tumor cell apoptotic sensitivity during the cell cycle (Review).". International Journal of Molecular Medicine 6, no. 5 (2000): 503-510. https://doi.org/10.3892/ijmm.6.5.503
Copy and paste a formatted citation
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Spandidos Publications style
Smith D, Gao G, Zhang X, Wang G and Dou Q: Regulation of tumor cell apoptotic sensitivity during the cell cycle (Review).. Int J Mol Med 6: 503-510, 2000.
APA
Smith, D., Gao, G., Zhang, X., Wang, G., & Dou, Q. (2000). Regulation of tumor cell apoptotic sensitivity during the cell cycle (Review).. International Journal of Molecular Medicine, 6, 503-510. https://doi.org/10.3892/ijmm.6.5.503
MLA
Smith, D., Gao, G., Zhang, X., Wang, G., Dou, Q."Regulation of tumor cell apoptotic sensitivity during the cell cycle (Review).". International Journal of Molecular Medicine 6.5 (2000): 503-510.
Chicago
Smith, D., Gao, G., Zhang, X., Wang, G., Dou, Q."Regulation of tumor cell apoptotic sensitivity during the cell cycle (Review).". International Journal of Molecular Medicine 6, no. 5 (2000): 503-510. https://doi.org/10.3892/ijmm.6.5.503
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