Trypsinogen expression in colorectal cancers.

  • Authors:
    • K Oyama
    • T Ohta
    • G I Nishimura
    • A Elnemr
    • T Yasui
    • T Fujimura
    • S Fushida
    • H Kitagawa
    • M Kayahara
    • T Terada
    • K Miwa
  • View Affiliations

  • Published online on: November 1, 2000     https://doi.org/10.3892/ijmm.6.5.543
  • Pages: 543-551
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Abstract

The purpose of this study was to evaluate the trypsinogen expression in human colorectal cancers. We observed the trypsinogen-1 mRNA expression in five of ten human colorectal cancer cell lines by reverse transcriptase-polymerase chain reaction (RT-PCR), and gelatinolytic activity in conditioned medium of cancer cells at acidic pH by gelatin zymography. Furthermore, trypsinogen protein expression was observed in 68 out of 154 (44.2%) surgical specimens of colorectal cancer immunohistochemically. However, there was no statistically significant relationship between the trypsinogen expression and the clinicopathological findings. These findings suggest that trypsinogen might be involved in cancer invasion and metastasis throughout the cancer progression.

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Nov 2000
Volume 6 Issue 5

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Oyama K, Ohta T, Nishimura G, Elnemr A, Yasui T, Fujimura T, Fushida S, Kitagawa H, Kayahara M, Terada T, Terada T, et al: Trypsinogen expression in colorectal cancers.. Int J Mol Med 6: 543-551, 2000
APA
Oyama, K., Ohta, T., Nishimura, G., Elnemr, A., Yasui, T., Fujimura, T. ... Miwa, K. (2000). Trypsinogen expression in colorectal cancers.. International Journal of Molecular Medicine, 6, 543-551. https://doi.org/10.3892/ijmm.6.5.543
MLA
Oyama, K., Ohta, T., Nishimura, G., Elnemr, A., Yasui, T., Fujimura, T., Fushida, S., Kitagawa, H., Kayahara, M., Terada, T., Miwa, K."Trypsinogen expression in colorectal cancers.". International Journal of Molecular Medicine 6.5 (2000): 543-551.
Chicago
Oyama, K., Ohta, T., Nishimura, G., Elnemr, A., Yasui, T., Fujimura, T., Fushida, S., Kitagawa, H., Kayahara, M., Terada, T., Miwa, K."Trypsinogen expression in colorectal cancers.". International Journal of Molecular Medicine 6, no. 5 (2000): 543-551. https://doi.org/10.3892/ijmm.6.5.543