No association between an intronic biallelic polymorphism of the FE65 gene and Alzheimer's disease.

Papassotiropoulos,A; Bagli,M; Becker,K; Jessen,F; Maier,W; Rao,M L; Ludwig,M; Heun,R

doi:10.3892/ijmm.6.5.587

Nov 2000 Volume 6 Issue 5

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Nov 2000 Volume 6 Issue 5

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Article

No association between an intronic biallelic polymorphism of the FE65 gene and Alzheimer's disease.

Authors:
- A Papassotiropoulos
- M Bagli
- K Becker
- F Jessen
- W Maier
- M L Rao
- M Ludwig
- R Heun
View Affiliations / Copyright

Affiliations: Department of Psychiatry Research, University of Zurich, CH-8029 Zurich, Switzerland. papas@bli.unizh.ch
Pages: 587-596
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Published online on: November 1, 2000

https://doi.org/10.3892/ijmm.6.5.587
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Abstract

The cleavage of the amyloid precursor protein (APP) into amyloidogenic components (Abeta) is a central event in the pathogenesis of Alzheimer's disease (AD). FE65 is a protein that is involved in APP metabolism and may facilitate the production of Abeta. Recently, an intronic polymorphism of the gene encoding FE65 (FE65) was associated with altered risk for the development of sporadic AD. In our sample of 102 AD patients and 351 non-demented controls we did not replicate the association between FE65 and AD. Moreover, we observed no risk-modifying interaction and no linkage disequilibrium between FE65 and the gene encoding the acid protease cathepsin D (catD), which - like FE65 - is involved in APP metabolism and is also located on chromosome 11p15. We conclude that, whereas FE65 is implicated in AD pathology, the gene encoding FE65 does not appear to confer a substantial risk for AD.

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

No association between an intronic biallelic polymorphism of the FE65 gene and Alzheimer's disease.

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