Activation of FcεRI-positive eosinophils in bullous pemphigoid

  • Authors:
    • M. Kasahara-Imamura
    • H. Hosokawa
    • N. Maekawa
    • T. Horio
  • View Affiliations

  • Published online on: March 1, 2001     https://doi.org/10.3892/ijmm.7.3.249
  • Pages: 249-253
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Abstract

Bullous pemphigoid (BP) is an autoimmune disease frequently occurring in elderly persons. It has been reported that 92-kDa gelatinase released from eosinophils cleaves the extracellular domain of BP180 protein, suggesting a direct role of eosinophils in bulla formation in this disease. The expression of the high-affinity IgE receptor, FcεRI, on eosinophils was examined in patient with BP. Samples of affected skin obtained from 7 patients with BP were stained immunohistochemically by the alkaline phosphatase anti-alkaline phosphatase (APAAP) method and mirror sections were examined. Eosinophils were present at a rate of 1.0-19.0% in lesions of the dermis, and the number of IgE-positive cells exceeded that of FcεRI-positive cells in all cases. These cells were not detected in the epidermis, and examination of mirror sections confirmed that the FcεRI-positive cells corresponded to eosinophils. It has been demonstrated that FcεRI-positive cells are involved in the dermal lesions of BP. The activation of eosinophils by FcεRI may participate in the pathogenesis of BP by triggering the degranulation of mast cells.

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March 2001
Volume 7 Issue 3

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Kasahara-Imamura M, Hosokawa H, Maekawa N and Horio T: Activation of FcεRI-positive eosinophils in bullous pemphigoid. Int J Mol Med 7: 249-253, 2001
APA
Kasahara-Imamura, M., Hosokawa, H., Maekawa, N., & Horio, T. (2001). Activation of FcεRI-positive eosinophils in bullous pemphigoid. International Journal of Molecular Medicine, 7, 249-253. https://doi.org/10.3892/ijmm.7.3.249
MLA
Kasahara-Imamura, M., Hosokawa, H., Maekawa, N., Horio, T."Activation of FcεRI-positive eosinophils in bullous pemphigoid". International Journal of Molecular Medicine 7.3 (2001): 249-253.
Chicago
Kasahara-Imamura, M., Hosokawa, H., Maekawa, N., Horio, T."Activation of FcεRI-positive eosinophils in bullous pemphigoid". International Journal of Molecular Medicine 7, no. 3 (2001): 249-253. https://doi.org/10.3892/ijmm.7.3.249