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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
Journal Cover
March 2001 Volume 7 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
March 2001 Volume 7 Issue 3

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Article

Prevention of concanavalin A-induced mice hepatitis by molsidomine

  • Authors:
    • Toshihiro Okamoto
    • Yoriko Masuda
    • Toru Kawasaki
  • View Affiliations / Copyright

    Affiliations: Research Laboratories, Nippon Chemiphar Co., Ltd., Misato, Saitama 341-0005, Japan
  • Pages: 307-309
    |
    Published online on: March 1, 2001
       https://doi.org/10.3892/ijmm.7.3.307
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Abstract

Molsidomine is effective in reducing portal hypertension in cirrhosis, but its effect on hepatitis is not known. In the present study, the effect of molsidomine on hepatitis was examined using mouse concanavalin A (Con A)-induced hepatitis and mouse anti-Fas antibody-induced hepatitis. Treatment of mice with Con A caused elevation of plasma alanine aminotransferase (ALT) at 8 and 24 h (n=4). Pretreatment of mice with molsidomine (3, 10, 30 and 100 mg/kg, i.p.) prevented Con A-induced hepatitis. Treatment of mice with anti-Fas antibody (150 μg/kg, i.v.) caused elevation of plasma ALT at 3.5 h. Pretreatment mice with molsidomine (10 mg/kg, i.p.) showed only 47% inhibition of anti-Fas antibody caused elevation of plasma ALT. The present results showed effectiveness of molsidomine in preventing Con A-induced mice hepatitis.

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Copy and paste a formatted citation
Spandidos Publications style
Okamoto T, Masuda Y and Kawasaki T: Prevention of concanavalin A-induced mice hepatitis by molsidomine. Int J Mol Med 7: 307-309, 2001.
APA
Okamoto, T., Masuda, Y., & Kawasaki, T. (2001). Prevention of concanavalin A-induced mice hepatitis by molsidomine. International Journal of Molecular Medicine, 7, 307-309. https://doi.org/10.3892/ijmm.7.3.307
MLA
Okamoto, T., Masuda, Y., Kawasaki, T."Prevention of concanavalin A-induced mice hepatitis by molsidomine". International Journal of Molecular Medicine 7.3 (2001): 307-309.
Chicago
Okamoto, T., Masuda, Y., Kawasaki, T."Prevention of concanavalin A-induced mice hepatitis by molsidomine". International Journal of Molecular Medicine 7, no. 3 (2001): 307-309. https://doi.org/10.3892/ijmm.7.3.307
Copy and paste a formatted citation
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Spandidos Publications style
Okamoto T, Masuda Y and Kawasaki T: Prevention of concanavalin A-induced mice hepatitis by molsidomine. Int J Mol Med 7: 307-309, 2001.
APA
Okamoto, T., Masuda, Y., & Kawasaki, T. (2001). Prevention of concanavalin A-induced mice hepatitis by molsidomine. International Journal of Molecular Medicine, 7, 307-309. https://doi.org/10.3892/ijmm.7.3.307
MLA
Okamoto, T., Masuda, Y., Kawasaki, T."Prevention of concanavalin A-induced mice hepatitis by molsidomine". International Journal of Molecular Medicine 7.3 (2001): 307-309.
Chicago
Okamoto, T., Masuda, Y., Kawasaki, T."Prevention of concanavalin A-induced mice hepatitis by molsidomine". International Journal of Molecular Medicine 7, no. 3 (2001): 307-309. https://doi.org/10.3892/ijmm.7.3.307
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