A combination analysis of p53 and p21 in gastric carcinoma as a strong indicator for prognosis

  • Authors:
    • Masafumi Ogawa
    • Naoyoshi Onoda
    • Kiyoshi Maeda
    • Yasuyuki Kato
    • Bunzo Nakata
    • Soon-Myoung Kang
    • Michio Sowa
    • Kosei Hirakawa
  • View Affiliations

  • Published online on: May 1, 2001     https://doi.org/10.3892/ijmm.7.5.479
  • Pages: 479-483
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Abstract

We studied p53 and p21 expression simultaneously in gastric carcinoma tissues to investigate the clinical significance of p53-p21 pathway in this disease. One hundred sixty-four primary gastric carcinoma specimens were immunohistochemically stained for p53 and p21 protein, and clinicopathological features of the cases were examined. P53 was stained negatively, while p21 was stained positively in each normal stomach epithelium. P53, and p21 positive staining was observed in 82 (50%) and 61 (37.2%) tumors, respectively. Unexpectingly, no correlation was found between p53 and p21 staining status. Tumors demonstrating preserved p53-p21 pathway [p53(-)/p21(+)], observed in 20.1% of the tumors, displayed less aggressive characteristics, and no recurrent disease after curative resection. While tumors demonstrating disrupted p53-p21 pathway [p53(+)/p21(-)], observed in 32.9% of the tumors, displayed significantly more aggressive characteristics, poorer survival and higher recurrence rate than the tumors demonstrating other staining patterns. P53-p21 pathway was widely altered in gastric carcinomas. The combined evaluation of p53 and p21 expression in gastric carcinoma tissues is suggested to have clinical importance by indicating not only the malignant potential of each tumor, but also the prognosis of this disease.

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May 2001
Volume 7 Issue 5

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Ogawa M, Onoda N, Maeda K, Kato Y, Nakata B, Kang S, Sowa M and Hirakawa K: A combination analysis of p53 and p21 in gastric carcinoma as a strong indicator for prognosis. Int J Mol Med 7: 479-483, 2001
APA
Ogawa, M., Onoda, N., Maeda, K., Kato, Y., Nakata, B., Kang, S. ... Hirakawa, K. (2001). A combination analysis of p53 and p21 in gastric carcinoma as a strong indicator for prognosis. International Journal of Molecular Medicine, 7, 479-483. https://doi.org/10.3892/ijmm.7.5.479
MLA
Ogawa, M., Onoda, N., Maeda, K., Kato, Y., Nakata, B., Kang, S., Sowa, M., Hirakawa, K."A combination analysis of p53 and p21 in gastric carcinoma as a strong indicator for prognosis". International Journal of Molecular Medicine 7.5 (2001): 479-483.
Chicago
Ogawa, M., Onoda, N., Maeda, K., Kato, Y., Nakata, B., Kang, S., Sowa, M., Hirakawa, K."A combination analysis of p53 and p21 in gastric carcinoma as a strong indicator for prognosis". International Journal of Molecular Medicine 7, no. 5 (2001): 479-483. https://doi.org/10.3892/ijmm.7.5.479