Effect of aging and hypertension on β-myosin heavy chain in heart of spontaneously hypertensive rats

  • Authors:
    • V. Compagno
    • I. Di Liegro
    • A. Cestelli
    • M. Donatelli
  • View Affiliations

  • Published online on: May 1, 2001     https://doi.org/10.3892/ijmm.7.5.507
  • Pages: 507-508
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Abstract

During aging rat myocardium undergoes structural changes characterized by a shift in the synthesis of myosin heavy chain (MHC) from V1 isoform, composed of two α-MHC, to V3 isoform, composed of two β-MHC. In rat, besides ageing, cardiac hypertrophy as adaptive response to a superimposed pressure load (such as hypertension) is characterized by predominance of V3 myosin isoform. The aim of our study was to evaluate the expression of β-MHC in right (RV) and left (LV) ventricles of spontaneously hypertensive rats (SHRs), a well defined animal model of hypertension, in relation to aging. We used very young (8-week old) and young (15-week old) SHRs and age-matched normotensive Harlan Sprague-Dawley control rats. By Western analysis, we found that β-MHC is already present in both RV and LV of 8-week old SHRs, and is markedly predominant in RV and LV of 15-week old SHRs, when compared with age-matched control rats. Our study showed that the shift to V3 myosin isoform in SHRs is an early event, resembling accelerated senescence. We have also demonstrated that β-MHC is actively synthesized also in young (15-week old) normal rats.

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May 2001
Volume 7 Issue 5

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Compagno V, Di Liegro I, Cestelli A and Donatelli M: Effect of aging and hypertension on β-myosin heavy chain in heart of spontaneously hypertensive rats. Int J Mol Med 7: 507-508, 2001
APA
Compagno, V., Di Liegro, I., Cestelli, A., & Donatelli, M. (2001). Effect of aging and hypertension on β-myosin heavy chain in heart of spontaneously hypertensive rats. International Journal of Molecular Medicine, 7, 507-508. https://doi.org/10.3892/ijmm.7.5.507
MLA
Compagno, V., Di Liegro, I., Cestelli, A., Donatelli, M."Effect of aging and hypertension on β-myosin heavy chain in heart of spontaneously hypertensive rats". International Journal of Molecular Medicine 7.5 (2001): 507-508.
Chicago
Compagno, V., Di Liegro, I., Cestelli, A., Donatelli, M."Effect of aging and hypertension on β-myosin heavy chain in heart of spontaneously hypertensive rats". International Journal of Molecular Medicine 7, no. 5 (2001): 507-508. https://doi.org/10.3892/ijmm.7.5.507