Fine mapping of the PTGFR gene to 1p31 region and mutation analysis in human breast cancer

  • Authors:
    • Khalid Sossey-Alaoui
    • Eiko Kitamura
    • John K. Cowell
  • View Affiliations

  • Published online on: May 1, 2001     https://doi.org/10.3892/ijmm.7.5.543
  • Pages: 543-546
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

The 1p31 chromosomal region shows loss of heterozygosity (LOH) in up to 50% of human breast cancer, indicating the presence of a tumor suppressor gene at this location. Many efforts have been made to identify candidate genes responsible for breast cancer on the short arm of chromosome 1. It was shown that prostaglandins have been implicated in the tumorigenesis pathway, perhaps via interactions with their cell surface receptors. The prostaglandin F2 receptor gene (PTGFR) was tentatively mapped to 1p31 adjacent to the region undergoing LOH in human breast cancer. We undertook a mutation study in 34 sporadic human breast tumors using a variant of SSCP, incorporation PCR SSCP (IPS). Several nucleotide variants were detected in different tumors. Here we report the nature of these nucleotide changes and the possible involvement of the PTGFR gene in the etiology of human cancer.

Related Articles

Journal Cover

May 2001
Volume 7 Issue 5

Print ISSN: 1107-3756
Online ISSN:1791-244X

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Sossey-Alaoui K, Kitamura E and Cowell JK: Fine mapping of the PTGFR gene to 1p31 region and mutation analysis in human breast cancer. Int J Mol Med 7: 543-546, 2001
APA
Sossey-Alaoui, K., Kitamura, E., & Cowell, J.K. (2001). Fine mapping of the PTGFR gene to 1p31 region and mutation analysis in human breast cancer. International Journal of Molecular Medicine, 7, 543-546. https://doi.org/10.3892/ijmm.7.5.543
MLA
Sossey-Alaoui, K., Kitamura, E., Cowell, J. K."Fine mapping of the PTGFR gene to 1p31 region and mutation analysis in human breast cancer". International Journal of Molecular Medicine 7.5 (2001): 543-546.
Chicago
Sossey-Alaoui, K., Kitamura, E., Cowell, J. K."Fine mapping of the PTGFR gene to 1p31 region and mutation analysis in human breast cancer". International Journal of Molecular Medicine 7, no. 5 (2001): 543-546. https://doi.org/10.3892/ijmm.7.5.543