Decreased levels of precursor transforming growth factor β1 in human colorectal cancer

  • Authors:
    • Jan Dimberg
    • Anders Hugander
    • Allan Sirsjo
  • View Affiliations

  • Published online on: June 1, 2001     https://doi.org/10.3892/ijmm.7.6.597
  • Pages: 597-601
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Transforming growth factor (TGF) β1 is a growth factor with wide-ranging effects on proliferation, differentiation, immunosuppression, apoptosis and matrix remodelling. TGFβ1 seems to have an antitumorigenic role in the gastrointestinal tract but may also be associated with the development of colorectal cancer. Initially, TGFβ1 is produced in a latent (precursor) form in epithelial cells and then is activated by a not clearly understood multistep process. In this study, we analysed precursor TGFβ1 protein expression (n=40) and TGFβ1 gene expression (n=49) in human colorectal adenocarcinomas and 49 normal adjacent tissue. Out of these 49 normal tissues 40 were matched. Western blot analysis revealed that the precursor TGFβ1 protein levels were generally lower in colorectal cancerous tissue compared to adjacent non-cancerous tissue (P<0.001). Furthermore, with real-time PCR our results cannot reflect a statistically significant difference in TGFβ1 gene expression between the tumour tissue and normal tissue. These finds indicate that it is likely that there are mechanisms which control precursor TGFβ1 protein expression by factor(s) at the level of pre-translation of the TGFβ1 transcript and/or at the level of post-translation of the TGFβ1 protein in the tumours. This process may be related to carcinogenesis and poses the question whether the suppression of the precursor TGFβ1 is an early event, in vivo, in the human colorectal adenoma-carcinoma sequence.

Related Articles

Journal Cover

June 2001
Volume 7 Issue 6

Print ISSN: 1107-3756
Online ISSN:1791-244X

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Dimberg J, Hugander A and Sirsjo A: Decreased levels of precursor transforming growth factor β1 in human colorectal cancer. Int J Mol Med 7: 597-601, 2001
APA
Dimberg, J., Hugander, A., & Sirsjo, A. (2001). Decreased levels of precursor transforming growth factor β1 in human colorectal cancer. International Journal of Molecular Medicine, 7, 597-601. https://doi.org/10.3892/ijmm.7.6.597
MLA
Dimberg, J., Hugander, A., Sirsjo, A."Decreased levels of precursor transforming growth factor β1 in human colorectal cancer". International Journal of Molecular Medicine 7.6 (2001): 597-601.
Chicago
Dimberg, J., Hugander, A., Sirsjo, A."Decreased levels of precursor transforming growth factor β1 in human colorectal cancer". International Journal of Molecular Medicine 7, no. 6 (2001): 597-601. https://doi.org/10.3892/ijmm.7.6.597