Potentiation by methyl pyruvate of GLP-1 insulinotropic action in normal rats

  • Authors:
    • I. Valverde
    • J. Cancelas
    • M. L. Villanueva-Penacarrillo
    • W. J. Malaisse
  • View Affiliations

  • Published online on: June 1, 2001     https://doi.org/10.3892/ijmm.7.6.621
  • Pages: 621-623
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Abstract

Methyl pyruvate (MP) stimulates insulin release both in vivo and in vitro. The present study aims at investigating whether MP is also able to enhance the B-cell secretory response to glucagon-like peptide 1 (GLP-1). In anaesthetized rats receiving a primed constant infusion of MP, the ester augmented plasma insulin concentration before GLP-1 injection and potentiated the insulinotropic action of the intestinal hormone. MP infusion also augmented plasma D-glucose concentration, whether in the absence or presence of GLP-1. A further rise in plasma D-glucose concentration was observed when the infusion of MP was halted, this coinciding with a fall in plasma insulin concentration. Whilst documenting that MP indeed enhances the B-cell secretory response to GLP-1, these findings do not suggest that MP is an appropriate tool for optimizing the hypoglycaemic action of the enteric hormone in the treatment of type-2 diabetes mellitus.

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June 2001
Volume 7 Issue 6

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Valverde I, Cancelas J, Villanueva-Penacarrillo ML and Malaisse WJ: Potentiation by methyl pyruvate of GLP-1 insulinotropic action in normal rats. Int J Mol Med 7: 621-623, 2001
APA
Valverde, I., Cancelas, J., Villanueva-Penacarrillo, M.L., & Malaisse, W.J. (2001). Potentiation by methyl pyruvate of GLP-1 insulinotropic action in normal rats. International Journal of Molecular Medicine, 7, 621-623. https://doi.org/10.3892/ijmm.7.6.621
MLA
Valverde, I., Cancelas, J., Villanueva-Penacarrillo, M. L., Malaisse, W. J."Potentiation by methyl pyruvate of GLP-1 insulinotropic action in normal rats". International Journal of Molecular Medicine 7.6 (2001): 621-623.
Chicago
Valverde, I., Cancelas, J., Villanueva-Penacarrillo, M. L., Malaisse, W. J."Potentiation by methyl pyruvate of GLP-1 insulinotropic action in normal rats". International Journal of Molecular Medicine 7, no. 6 (2001): 621-623. https://doi.org/10.3892/ijmm.7.6.621