Morphine reduces herpes simplex virus-1 pathogenesis in the murine flank

  • Authors:
    • Benjamin S. Weeks
    • Ninche I. Alston
    • Patrick Cadet
    • Wei Zhu
    • Christos Rialas
    • George B. Stefano
  • View Affiliations

  • Published online on: September 1, 2001     https://doi.org/10.3892/ijmm.8.3.303
  • Pages: 303-307
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Abstract

Here we investigate the effect of morphine on herpes simplex virus-1 (HSV-1) pathogenesis using a murine flank scarification model. Murine flank scarification with HSV-1 results in primary lesions at the site of inoculation within three days and lesions at secondary sites within four days. The lesions are scored based on lesion size. Applying 0.1 mM morphine to the skin one-day post inoculation tested the effect of morphine on the formation of the herpes lesion. On days three through five, mice treated with morphine developed lesions with scores half of that observed in untreated animals, however, skin viral titers on these days were equivalent. Further, 1.0 μM morphine did not effect the replication rate of HSV-1 in Vero cells. Taken together, these data suggest the morphine reduced HSV-1 pathogenesis by modifying the host response to HSV-1 infection and not by reducing viral replication rates.

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September 2001
Volume 8 Issue 3

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Weeks BS, Alston NI, Cadet P, Zhu W, Rialas C and Stefano GB: Morphine reduces herpes simplex virus-1 pathogenesis in the murine flank. Int J Mol Med 8: 303-307, 2001
APA
Weeks, B.S., Alston, N.I., Cadet, P., Zhu, W., Rialas, C., & Stefano, G.B. (2001). Morphine reduces herpes simplex virus-1 pathogenesis in the murine flank. International Journal of Molecular Medicine, 8, 303-307. https://doi.org/10.3892/ijmm.8.3.303
MLA
Weeks, B. S., Alston, N. I., Cadet, P., Zhu, W., Rialas, C., Stefano, G. B."Morphine reduces herpes simplex virus-1 pathogenesis in the murine flank". International Journal of Molecular Medicine 8.3 (2001): 303-307.
Chicago
Weeks, B. S., Alston, N. I., Cadet, P., Zhu, W., Rialas, C., Stefano, G. B."Morphine reduces herpes simplex virus-1 pathogenesis in the murine flank". International Journal of Molecular Medicine 8, no. 3 (2001): 303-307. https://doi.org/10.3892/ijmm.8.3.303