Allelic variation of BAT-26 and BAT-40 poly-adenine repeat loci in North Indians

Mukherjee,Monisha; Vaish,Minal; Mittal,R. D.; Mittal,Balraj

doi:10.3892/ijmm.9.1.91

January 2002 Volume 9 Issue 1

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January 2002 Volume 9 Issue 1

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Article

Allelic variation of BAT-26 and BAT-40 poly-adenine repeat loci in North Indians

Authors:
- Monisha Mukherjee
- Minal Vaish
- R. D. Mittal
- Balraj Mittal
View Affiliations / Copyright

Affiliations: Department of Medical Genetics, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow 226014, India
Pages: 91-94
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Published online on: January 1, 2002

https://doi.org/10.3892/ijmm.9.1.91
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Abstract

Analysis of mononucleotide repeats BAT-26 and BAT-40 in North Indians revealed that there were germline polymorphisms at both the loci. We evaluated BAT-26 and BAT-40 in 100 normal healthy individuals from North India. The DNA from normal blood was PCR amplified using primers flanking the BAT-26 and BAT-40 loci. The allelic variation of BAT-26 and BAT-40 ranged between 117-130 and 94-112 bp respectively. The most frequent BAT-26 allele was 122 bp, which corresponded to 26 repeats and had a frequency of 32% while that of BAT-40 was 109 bp corresponding to 39 repeats with a frequency of 26%. These results suggest that polymorphisms in these poly-adenine repeat loci limit their applicability in studying the microsatellite instability in cancers.

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Allelic variation of BAT-26 and BAT-40 poly-adenine repeat loci in North Indians

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