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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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April 2002 Volume 9 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Microdissection based high resolution multicolor banding for all 24 human chromosomes

  • Authors:
    • Thomas Liehr
    • Anita Heller
    • Heike Starke
    • Nikolai Rubtsov
    • Vladimir Trifonov
    • Kristin Mrasek
    • Anja Weise
    • Alma Kuechler
    • Uwe Claussen

  • View Affiliations / Copyright

    Affiliations: Institut fur Humangenetik und Anthropologie, Postfach, D-07740 Jena, Germany. i8lith@mti-n.mti.uni-jena.de
  • Pages: 335-339
    |
    Published online on: April 1, 2002
       https://doi.org/10.3892/ijmm.9.4.335
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Abstract

The multicolor-banding (MCB) approach allows the differentiation of chromosome region specific areas at the band and sub-band level and is based on region-specific microdissection libraries producing changing fluorescence intensity ratios along the chromosomes. The latter are used to assign different pseudocolors to specific chromosomal regions. We present the complete set of 138 region-specific microdissection libraries for the entire human genome and the resulting MCB patterns for all human chromosomes at the 450-550 band level. In the present work, the creation and handling of the microdissection libraries is detailed for the first time. Additionally, the unique possibilities of the MCB technique to adjust the pseudocolor bands according to the necessities of the studied case is presented in exemplarity. In conclusion, the MCB-technique is a high resolution alternative to other FISH based chromosome banding approaches and suited to clarify, which changes appeared in complex chromosomal rearrangements.

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Copy and paste a formatted citation
Spandidos Publications style
Liehr T, Heller A, Starke H, Rubtsov N, Trifonov V, Mrasek K, Weise A, Kuechler A and Claussen U: Microdissection based high resolution multicolor banding for all 24 human chromosomes. Int J Mol Med 9: 335-339, 2002.
APA
Liehr, T., Heller, A., Starke, H., Rubtsov, N., Trifonov, V., Mrasek, K. ... Claussen, U. (2002). Microdissection based high resolution multicolor banding for all 24 human chromosomes. International Journal of Molecular Medicine, 9, 335-339. https://doi.org/10.3892/ijmm.9.4.335
MLA
Liehr, T., Heller, A., Starke, H., Rubtsov, N., Trifonov, V., Mrasek, K., Weise, A., Kuechler, A., Claussen, U."Microdissection based high resolution multicolor banding for all 24 human chromosomes". International Journal of Molecular Medicine 9.4 (2002): 335-339.
Chicago
Liehr, T., Heller, A., Starke, H., Rubtsov, N., Trifonov, V., Mrasek, K., Weise, A., Kuechler, A., Claussen, U."Microdissection based high resolution multicolor banding for all 24 human chromosomes". International Journal of Molecular Medicine 9, no. 4 (2002): 335-339. https://doi.org/10.3892/ijmm.9.4.335
Copy and paste a formatted citation
x
Spandidos Publications style
Liehr T, Heller A, Starke H, Rubtsov N, Trifonov V, Mrasek K, Weise A, Kuechler A and Claussen U: Microdissection based high resolution multicolor banding for all 24 human chromosomes. Int J Mol Med 9: 335-339, 2002.
APA
Liehr, T., Heller, A., Starke, H., Rubtsov, N., Trifonov, V., Mrasek, K. ... Claussen, U. (2002). Microdissection based high resolution multicolor banding for all 24 human chromosomes. International Journal of Molecular Medicine, 9, 335-339. https://doi.org/10.3892/ijmm.9.4.335
MLA
Liehr, T., Heller, A., Starke, H., Rubtsov, N., Trifonov, V., Mrasek, K., Weise, A., Kuechler, A., Claussen, U."Microdissection based high resolution multicolor banding for all 24 human chromosomes". International Journal of Molecular Medicine 9.4 (2002): 335-339.
Chicago
Liehr, T., Heller, A., Starke, H., Rubtsov, N., Trifonov, V., Mrasek, K., Weise, A., Kuechler, A., Claussen, U."Microdissection based high resolution multicolor banding for all 24 human chromosomes". International Journal of Molecular Medicine 9, no. 4 (2002): 335-339. https://doi.org/10.3892/ijmm.9.4.335
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