NSAID zaltoprofen improves the decrease in body weight in rodent sickness behavior models: Proposed new applications of NSAIDs (Review)

Okamoto,Toshihiro

doi:10.3892/ijmm.9.4.369

April 2002 Volume 9 Issue 4

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April 2002 Volume 9 Issue 4

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Review

NSAID zaltoprofen improves the decrease in body weight in rodent sickness behavior models: Proposed new applications of NSAIDs (Review)

Authors:
- Toshihiro Okamoto
View Affiliations / Copyright

Affiliations: Research Laboratories, Nippon Chemiphar Co. Ltd., Saitama 341-0005, Japan
Pages: 369-372
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Published online on: April 1, 2002

https://doi.org/10.3892/ijmm.9.4.369
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Abstract

In infectious diseases and during inflammation, anorexia, loss of body weight, malaise, fatigue and depression are induced. These symptoms are correctively called , and the central actions of cytokines play a role in their induction. The loss of body weight in cancer cachexia is also a result of development of sickness behaviors. It has been reported that the administration of NSAID ibuprofen to patients with cancer cachexia improves the loss in body weight. We studied the effect of NSAID on the loss of body weight by using rodent sickness behavior models. We have reported that sickness behaviors such as anorexia, decrease in body weight, and loss of locomotor activity are induced in concanavalin A (Con A)-induced mouse hepatitis and carbon tetrachloride-induced rat hepatitis. Zaltoprofen is a non-steroidal anti-inflammatory drug (NSAID) causes potent inhibition of cyclooxygenase-2 with fewer side effects on the gastrointestinal tract. Zaltoprofen improves the loss in body weight in both Con A-treated mice and carbon tetrachloride-treated rats. These results suggest the possible application of zaltoprofen for the treatment of sickness behaviors including loss of body weight occurring in cancer cachexia.

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

NSAID zaltoprofen improves the decrease in body weight in rodent sickness behavior models: Proposed new applications of NSAIDs (Review)

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Abstract

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