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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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April 2002 Volume 9 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

The environmental toxin 2,3,7,8-tetrachlorodibenzo-p-dioxin induces cytochrome P450 activity in high passage PC 3 and DU 145 human prostate cancer cell lines

  • Authors:
    • Katharina Schaufler
    • Petra Haslmayer
    • Walter Jager
    • Martina Pec
    • Theresia Thalhammer

  • View Affiliations / Copyright

    Affiliations: Department of Pathophysiology, University of Vienna, A-1090 Vienna, Austria
  • Pages: 411-416
    |
    Published online on: April 1, 2002
       https://doi.org/10.3892/ijmm.9.4.411
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Abstract

The study was conducted to investigate whether 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) induces cytochrome P450 (CYP) 1A1 and CYP1B1 via the aryl hydrocarbon receptor (AhR) in the hormone-independent human prostate cancer cell lines PC 3 and DU 145. No quantitative differences in the expression of AhR and its partner transcription factor ARNT were seen in low and high passage number PC 3 and DU 145 cells in the absence and presence of TCDD as assessed by RT-PCR and Western blotting. However, CYP1A1/1B1 activity, measured by the 7-ethoxyresorufin-O-deethylase (EROD) assay, was induced by 10 and 100 nM TCDD only in high passage number PC 3 and DU 145 cells (PC 3, 7.7- and 2-fold stimulation; DU 145, 8.5- and 19.7-fold stimulation). Besides stimulation of EROD activity, induction of the expression of CYP1A1 and, to a lesser extend, of CYP1B1 by TCDD was also demonstrated by RT-PCR and Western blotting. However, 1-100 nM TCDD did not significantly alter cell cycle distribution and cell growth for up to five days. The induction of CYP1A1 and CYP1B1 by TCCD in the hormone-independent prostate cancer cell lines suggests that CYP induction should be considered in patients with advanced prostate cancer. This could result in higher elimination rates of concomitant drugs metabolized by these particular CYP isoenzymes.

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Copy and paste a formatted citation
Spandidos Publications style
Schaufler K, Haslmayer P, Jager W, Pec M and Thalhammer T: The environmental toxin 2,3,7,8-tetrachlorodibenzo-p-dioxin induces cytochrome P450 activity in high passage PC 3 and DU 145 human prostate cancer cell lines. Int J Mol Med 9: 411-416, 2002.
APA
Schaufler, K., Haslmayer, P., Jager, W., Pec, M., & Thalhammer, T. (2002). The environmental toxin 2,3,7,8-tetrachlorodibenzo-p-dioxin induces cytochrome P450 activity in high passage PC 3 and DU 145 human prostate cancer cell lines. International Journal of Molecular Medicine, 9, 411-416. https://doi.org/10.3892/ijmm.9.4.411
MLA
Schaufler, K., Haslmayer, P., Jager, W., Pec, M., Thalhammer, T."The environmental toxin 2,3,7,8-tetrachlorodibenzo-p-dioxin induces cytochrome P450 activity in high passage PC 3 and DU 145 human prostate cancer cell lines". International Journal of Molecular Medicine 9.4 (2002): 411-416.
Chicago
Schaufler, K., Haslmayer, P., Jager, W., Pec, M., Thalhammer, T."The environmental toxin 2,3,7,8-tetrachlorodibenzo-p-dioxin induces cytochrome P450 activity in high passage PC 3 and DU 145 human prostate cancer cell lines". International Journal of Molecular Medicine 9, no. 4 (2002): 411-416. https://doi.org/10.3892/ijmm.9.4.411
Copy and paste a formatted citation
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Spandidos Publications style
Schaufler K, Haslmayer P, Jager W, Pec M and Thalhammer T: The environmental toxin 2,3,7,8-tetrachlorodibenzo-p-dioxin induces cytochrome P450 activity in high passage PC 3 and DU 145 human prostate cancer cell lines. Int J Mol Med 9: 411-416, 2002.
APA
Schaufler, K., Haslmayer, P., Jager, W., Pec, M., & Thalhammer, T. (2002). The environmental toxin 2,3,7,8-tetrachlorodibenzo-p-dioxin induces cytochrome P450 activity in high passage PC 3 and DU 145 human prostate cancer cell lines. International Journal of Molecular Medicine, 9, 411-416. https://doi.org/10.3892/ijmm.9.4.411
MLA
Schaufler, K., Haslmayer, P., Jager, W., Pec, M., Thalhammer, T."The environmental toxin 2,3,7,8-tetrachlorodibenzo-p-dioxin induces cytochrome P450 activity in high passage PC 3 and DU 145 human prostate cancer cell lines". International Journal of Molecular Medicine 9.4 (2002): 411-416.
Chicago
Schaufler, K., Haslmayer, P., Jager, W., Pec, M., Thalhammer, T."The environmental toxin 2,3,7,8-tetrachlorodibenzo-p-dioxin induces cytochrome P450 activity in high passage PC 3 and DU 145 human prostate cancer cell lines". International Journal of Molecular Medicine 9, no. 4 (2002): 411-416. https://doi.org/10.3892/ijmm.9.4.411
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