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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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May 2002 Volume 9 Issue 5

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Article

Interaction of the small GTPase Rac3 with NRBP, a protein with a kinase-homology domain

  • Authors:
    • Stijn De Langhe
    • Leena Haataja
    • Dinithi Senadheera
    • John Groffen
    • Nora Heisterkamp

  • View Affiliations / Copyright

    Affiliations: Division of Hematology/Oncology, Section of Molecular Carcinogenesis, Childrens Hospital of Los Angeles Research Institute and the Keck School of Medicine of the University of Southern California, Los Angeles, CA 90027, USA
  • Pages: 451-459
    |
    Published online on: May 1, 2002
       https://doi.org/10.3892/ijmm.9.5.451
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Abstract

The family of Rac small GTPases including Rac1, Rac2 and Rac3 regulate numerous cellular processes. Since the cellular functions of Rac3 have not been defined, constitutively active V12Rac3 was used to identify targets that transduce its signals. We here identify human NRBP as a Rac family-interacting protein. NRBP formed a complex with activated Rac3. NRBP contains a kinase-homology domain and exhibits an associated kinase activity. NRBP represents a novel family of evolutionarily conserved proteins with homologs in C. elegans, D. melanogaster, mouse and human. Overexpression of NRBP in COS-1 cells failed to activate possible downstream targets of Rac3 including the JNK pathway, the p38 pathway or actin cytoskeletal rearrangements. Also, NRBP failed to co-localize with actin-based stress fibers or microspikes, or with the subcortical actin. However, overexpression of NRBP caused a dramatic redistribution of the Golgi-associated marker p58 to more peripheral locations within the cell, consistent with an impairment of the ER to Golgi transport. Immunocytochemistry showed that NRBP and activated Rac3 co-localized to endomembranes and at the cell periphery in lamellipodia. These results suggest that NRBP functions in subcellular trafficking and may be directed to specific subcellular locations through interaction with small GTPases of the Rho family.

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Copy and paste a formatted citation
Spandidos Publications style
De Langhe S, Haataja L, Senadheera D, Groffen J and Heisterkamp N: Interaction of the small GTPase Rac3 with NRBP, a protein with a kinase-homology domain. Int J Mol Med 9: 451-459, 2002.
APA
De Langhe, S., Haataja, L., Senadheera, D., Groffen, J., & Heisterkamp, N. (2002). Interaction of the small GTPase Rac3 with NRBP, a protein with a kinase-homology domain. International Journal of Molecular Medicine, 9, 451-459. https://doi.org/10.3892/ijmm.9.5.451
MLA
De Langhe, S., Haataja, L., Senadheera, D., Groffen, J., Heisterkamp, N."Interaction of the small GTPase Rac3 with NRBP, a protein with a kinase-homology domain". International Journal of Molecular Medicine 9.5 (2002): 451-459.
Chicago
De Langhe, S., Haataja, L., Senadheera, D., Groffen, J., Heisterkamp, N."Interaction of the small GTPase Rac3 with NRBP, a protein with a kinase-homology domain". International Journal of Molecular Medicine 9, no. 5 (2002): 451-459. https://doi.org/10.3892/ijmm.9.5.451
Copy and paste a formatted citation
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Spandidos Publications style
De Langhe S, Haataja L, Senadheera D, Groffen J and Heisterkamp N: Interaction of the small GTPase Rac3 with NRBP, a protein with a kinase-homology domain. Int J Mol Med 9: 451-459, 2002.
APA
De Langhe, S., Haataja, L., Senadheera, D., Groffen, J., & Heisterkamp, N. (2002). Interaction of the small GTPase Rac3 with NRBP, a protein with a kinase-homology domain. International Journal of Molecular Medicine, 9, 451-459. https://doi.org/10.3892/ijmm.9.5.451
MLA
De Langhe, S., Haataja, L., Senadheera, D., Groffen, J., Heisterkamp, N."Interaction of the small GTPase Rac3 with NRBP, a protein with a kinase-homology domain". International Journal of Molecular Medicine 9.5 (2002): 451-459.
Chicago
De Langhe, S., Haataja, L., Senadheera, D., Groffen, J., Heisterkamp, N."Interaction of the small GTPase Rac3 with NRBP, a protein with a kinase-homology domain". International Journal of Molecular Medicine 9, no. 5 (2002): 451-459. https://doi.org/10.3892/ijmm.9.5.451
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