Selective induction of apoptosis by ar-turmerone isolated from turmeric (Curcuma longa L) in two human leukemia cell lines, but not in human stomach cancer cell line

  • Authors:
    • Y. Aratanechemuge
    • T. Komiya
    • H. Moteki
    • H. Katsuzaki
    • K. Imai
    • H. Hibasami
  • View Affiliations

  • Published online on: May 1, 2002     https://doi.org/10.3892/ijmm.9.5.481
  • Pages: 481-484
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Abstract

We have investigated the effects of ar-turmerone isolated from turmeric (Curcuma longa L) on DNA of human leukemia cell lines, Molt 4B, HL-60 and stomach cancer KATO III cells. It was found that selective induction of apoptosis by ar-turmerone was observed in human leukemia Molt 4B and HL-60 cells, but not in human stomach cancer KATO III cells. Morphological changes showing apoptotic bodies were observed in the human HL-60 and Molt 4B cells treated with ar-turmerone. The fragmentation of DNA by ar-turmerone to oligonucleosomal-sized fragments that is a characteristic of apoptosis was observed to be concentration- and time-dependent in Molt 4B and HL-60 cells, but not in KATO III cells. The data of the present study show that the suppression by ar-turmerone of growth of these leukemia cell lines results from the induction of apoptosis by this compound.

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May 2002
Volume 9 Issue 5

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Aratanechemuge Y, Komiya T, Moteki H, Katsuzaki H, Imai K and Hibasami H: Selective induction of apoptosis by ar-turmerone isolated from turmeric (Curcuma longa L) in two human leukemia cell lines, but not in human stomach cancer cell line. Int J Mol Med 9: 481-484, 2002.
APA
Aratanechemuge, Y., Komiya, T., Moteki, H., Katsuzaki, H., Imai, K., & Hibasami, H. (2002). Selective induction of apoptosis by ar-turmerone isolated from turmeric (Curcuma longa L) in two human leukemia cell lines, but not in human stomach cancer cell line. International Journal of Molecular Medicine, 9, 481-484. https://doi.org/10.3892/ijmm.9.5.481
MLA
Aratanechemuge, Y., Komiya, T., Moteki, H., Katsuzaki, H., Imai, K., Hibasami, H."Selective induction of apoptosis by ar-turmerone isolated from turmeric (Curcuma longa L) in two human leukemia cell lines, but not in human stomach cancer cell line". International Journal of Molecular Medicine 9.5 (2002): 481-484.
Chicago
Aratanechemuge, Y., Komiya, T., Moteki, H., Katsuzaki, H., Imai, K., Hibasami, H."Selective induction of apoptosis by ar-turmerone isolated from turmeric (Curcuma longa L) in two human leukemia cell lines, but not in human stomach cancer cell line". International Journal of Molecular Medicine 9, no. 5 (2002): 481-484. https://doi.org/10.3892/ijmm.9.5.481