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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
Journal Cover
May 2002 Volume 9 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
May 2002 Volume 9 Issue 5

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Article

Molecular profiling of high-risk neuroblastoma by cDNA array

  • Authors:
    • Iacopo Sardi
    • Veronica Tintori
    • Cinzia Marchi
    • Marinella Veltroni
    • A. Lippi
    • F. Tucci
    • A. Tamburini
    • G. Bernini
    • L. Faulkner

  • View Affiliations / Copyright

    Affiliations: Unita di Oncoematologia, Ospedale Pediatrico A. Meyer, 50132 Firenze, Italy. iacoposardi@hotmail.com
  • Pages: 541-545
    |
    Published online on: May 1, 2002
       https://doi.org/10.3892/ijmm.9.5.541
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Abstract

The aim of this study was to investigate gene expression changes in disseminated neuroblastoma by cDNA array technique. Three stage IV neuroblastomas and one neuroblastoma cell line (SK-N-FI) were analyzed. Expression profiles were confirmed by semiquantitative RT-PCR and in some instances by Northern blotting. Comparison of expression profiles identified several genes which were highly expressed as well as some which were down-regulated in tumor samples relatively to SK-N-FI cells. The tumors studied lacked N-myc overexpression, while showing up-regulation of basic trans-cription factors, growth factors and receptors such as NSEP, c-myc binding protein MM1, thymosin β10 (TMSB10), TNF-R superfamily member 10A (TNFRSF10A) and FZ9. These results suggest that cDNA array technology is a powerful tool to identify a set of genes involved in neuroblastoma genesis and progression. Thus, the sensitive cDNA array may provide new insight into many aspects of pediatric tumors and play crucial role in the administration of adjuvant therapy of patients with neuroblastoma.

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Copy and paste a formatted citation
Spandidos Publications style
Sardi I, Tintori V, Marchi C, Veltroni M, Lippi A, Tucci F, Tamburini A, Bernini G and Faulkner L: Molecular profiling of high-risk neuroblastoma by cDNA array. Int J Mol Med 9: 541-545, 2002.
APA
Sardi, I., Tintori, V., Marchi, C., Veltroni, M., Lippi, A., Tucci, F. ... Faulkner, L. (2002). Molecular profiling of high-risk neuroblastoma by cDNA array. International Journal of Molecular Medicine, 9, 541-545. https://doi.org/10.3892/ijmm.9.5.541
MLA
Sardi, I., Tintori, V., Marchi, C., Veltroni, M., Lippi, A., Tucci, F., Tamburini, A., Bernini, G., Faulkner, L."Molecular profiling of high-risk neuroblastoma by cDNA array". International Journal of Molecular Medicine 9.5 (2002): 541-545.
Chicago
Sardi, I., Tintori, V., Marchi, C., Veltroni, M., Lippi, A., Tucci, F., Tamburini, A., Bernini, G., Faulkner, L."Molecular profiling of high-risk neuroblastoma by cDNA array". International Journal of Molecular Medicine 9, no. 5 (2002): 541-545. https://doi.org/10.3892/ijmm.9.5.541
Copy and paste a formatted citation
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Spandidos Publications style
Sardi I, Tintori V, Marchi C, Veltroni M, Lippi A, Tucci F, Tamburini A, Bernini G and Faulkner L: Molecular profiling of high-risk neuroblastoma by cDNA array. Int J Mol Med 9: 541-545, 2002.
APA
Sardi, I., Tintori, V., Marchi, C., Veltroni, M., Lippi, A., Tucci, F. ... Faulkner, L. (2002). Molecular profiling of high-risk neuroblastoma by cDNA array. International Journal of Molecular Medicine, 9, 541-545. https://doi.org/10.3892/ijmm.9.5.541
MLA
Sardi, I., Tintori, V., Marchi, C., Veltroni, M., Lippi, A., Tucci, F., Tamburini, A., Bernini, G., Faulkner, L."Molecular profiling of high-risk neuroblastoma by cDNA array". International Journal of Molecular Medicine 9.5 (2002): 541-545.
Chicago
Sardi, I., Tintori, V., Marchi, C., Veltroni, M., Lippi, A., Tucci, F., Tamburini, A., Bernini, G., Faulkner, L."Molecular profiling of high-risk neuroblastoma by cDNA array". International Journal of Molecular Medicine 9, no. 5 (2002): 541-545. https://doi.org/10.3892/ijmm.9.5.541
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