Enhanced expression of Bcl-2 in lymphocytes infiltrating into the liver of patients with primary biliary cirrhosis

  • Authors:
    • A. Deguchi
    • K. Arima
    • T. Masaki
    • M. Yachida
    • S. Nakai
    • T. Ito
    • Y. Kita
    • K. Kurokohchi
    • S. Watanabe
    • S. Kuriyama
  • View Affiliations

  • Published online on: June 1, 2002     https://doi.org/10.3892/ijmm.9.6.571
  • Pages: 571-577
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Abstract

The Bcl-2 family proteins are important regulators of apoptosis and have been implicated in the occurrence of autoimmune diseases. There have been reports that Bcl-2-positive lymphocytes play important roles in pathogenesis of at least some types of autoimmune diseases, including autoimmune hepatitis. In this study, we examined the role of Bcl-2-positive lymphocytes in the development of primary biliary cirrhosis (PBC). The expression of Bcl-2 in lymphocytes infiltrating into the liver was evaluated from liver biopsy specimens of 25 patients with PBC (stage I/II/III/IV, 11/3/8/3) and 24 controls with chronic hepatitis B (CH-B) or chronic hepatitis C (CH-C). Bcl-2 expression in lymphocytes infiltrating into the liver was investigated by immunohistochemistry using a monoclonal antibody to Bcl-2 with an avidin-biotin complex system. Significant overexpression of Bcl-2 in lymphocytes infiltrating into the liver was observed in the early stage of PBC, especially in areas of destructed bile ducts. Most of Bcl-2-positive cells were CD45RO-positive helper T-cells visualized by the double staining method. These results suggest that Bcl-2-positive helper T-cells may have important roles in the pathogenesis of PBC.

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June 2002
Volume 9 Issue 6

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Deguchi A, Arima K, Masaki T, Yachida M, Nakai S, Ito T, Kita Y, Kurokohchi K, Watanabe S, Kuriyama S, Kuriyama S, et al: Enhanced expression of Bcl-2 in lymphocytes infiltrating into the liver of patients with primary biliary cirrhosis. Int J Mol Med 9: 571-577, 2002
APA
Deguchi, A., Arima, K., Masaki, T., Yachida, M., Nakai, S., Ito, T. ... Kuriyama, S. (2002). Enhanced expression of Bcl-2 in lymphocytes infiltrating into the liver of patients with primary biliary cirrhosis. International Journal of Molecular Medicine, 9, 571-577. https://doi.org/10.3892/ijmm.9.6.571
MLA
Deguchi, A., Arima, K., Masaki, T., Yachida, M., Nakai, S., Ito, T., Kita, Y., Kurokohchi, K., Watanabe, S., Kuriyama, S."Enhanced expression of Bcl-2 in lymphocytes infiltrating into the liver of patients with primary biliary cirrhosis". International Journal of Molecular Medicine 9.6 (2002): 571-577.
Chicago
Deguchi, A., Arima, K., Masaki, T., Yachida, M., Nakai, S., Ito, T., Kita, Y., Kurokohchi, K., Watanabe, S., Kuriyama, S."Enhanced expression of Bcl-2 in lymphocytes infiltrating into the liver of patients with primary biliary cirrhosis". International Journal of Molecular Medicine 9, no. 6 (2002): 571-577. https://doi.org/10.3892/ijmm.9.6.571