In search of a function for the E3B1/Abi2/Argbp1/NESH family (Review)

  • Authors:
    • Y. Ichigotani
    • K. Fujii
    • M. Hamaguchi
    • S. Matsuda
  • View Affiliations

  • Published online on: June 1, 2002     https://doi.org/10.3892/ijmm.9.6.591
  • Pages: 591-595
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Abstract

An E3B1/Abi2/Argbp1/NESH protein family has recently emerged from analysis of the sequence and structural similarities. These are adaptor proteins possessing homeobox homology domain, proline rich region and Src-homology 3 (SH3) domain that interact with Abl-family tyrosine kinases. Some of the members of this family are involved in cytoskeletal reorganization that plays important roles in membrane-ruffling, lamellipodia formation and cell migration. Furthermore, it seems likely that this family may also regulate cancer development through modulation of the oncogenic Abl kinase. The knowledge of this status is helpful in thinking of the regulatory mechanisms to cell metastasis and to malignant transformation of cancer. We discuss how these interesting molecules work and consider their involvement in cancer.

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June 2002
Volume 9 Issue 6

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Ichigotani Y, Fujii K, Hamaguchi M and Matsuda S: In search of a function for the E3B1/Abi2/Argbp1/NESH family (Review). Int J Mol Med 9: 591-595, 2002
APA
Ichigotani, Y., Fujii, K., Hamaguchi, M., & Matsuda, S. (2002). In search of a function for the E3B1/Abi2/Argbp1/NESH family (Review). International Journal of Molecular Medicine, 9, 591-595. https://doi.org/10.3892/ijmm.9.6.591
MLA
Ichigotani, Y., Fujii, K., Hamaguchi, M., Matsuda, S."In search of a function for the E3B1/Abi2/Argbp1/NESH family (Review)". International Journal of Molecular Medicine 9.6 (2002): 591-595.
Chicago
Ichigotani, Y., Fujii, K., Hamaguchi, M., Matsuda, S."In search of a function for the E3B1/Abi2/Argbp1/NESH family (Review)". International Journal of Molecular Medicine 9, no. 6 (2002): 591-595. https://doi.org/10.3892/ijmm.9.6.591