Decreased expression of the CCAAT/enhancer binding protein α gene involved in hepatocyte proliferation in human hepatocellular carcinomas
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- Published online on: June 1, 2002 https://doi.org/10.3892/ijmm.9.6.597
- Pages: 597-600
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Abstract
CCAAT/enhancer binding protein α (C/EBPα), expressed at a high level in liver, plays an important role in proliferation and differentiation of hepatocytes. Previous studies showed that an expression level of the C/EBPα gene in hepatocytes was downregulated in response to proliferation signals and that forced expression of the C/EBPα gene in a number of cells caused cell cycle arrest. We compared the expression level of the C/EBPα gene in surgical specimens between hepatocellular carcinoma and non-tumorous regions of the same patients. In 9 out of 13 cases, the expression level in the tumors was decreased compared with that in corresponding non-tumorous regions. Transfection of the C/EBPα gene into C/EBPα-negative human hepatocellular carcinoma HLF cells, however, did not influence the rate of cell proliferation or cell cycle. Our present data suggest that the expression of the C/EBPα gene was downregulated in the majority of human hepatocellular carcinoma but the expression may not be directly associated with impaired proliferative activity of hepatocellular carcinoma cells.