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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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August 2008 Volume 22 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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August 2008 Volume 22 Issue 2

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Article

Pyrogallol inhibits the growth of gastric cancer SNU-484 cells via induction of apoptosis

  • Authors:
    • Woo Hyun Park
    • Mee Na Park
    • Yong Hwan Han
    • Sang Woo Kim

  • View Affiliations / Copyright

    Affiliations: Department of Physiology, Medical School, Research Institute of Clinical Medicine, Chonbuk National University, JeonJu 561-180, Korea. parkwh71@chonbuk.ac.kr
  • Pages: 263-268
    |
    Published online on: August 1, 2008
       https://doi.org/10.3892/ijmm_00000018
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Abstract

Pyrogallol (PG) is a polyphenol compound and is known to be an O2·− generator. We evaluated the effects of PG on the growth of human gastric cancer SNU-484 cells in relation to the cell cycle and apoptosis. Dose-dependent inhibition of cell growth was observed in SNU-484 cells with an IC50 of ≈50 μM following treatment with PG for 72 h. DNA flow cytometric analysis indicated that treatment with PG generally did not induce the specific cell cycle phase arrest. Treatment with 50 μM PG induced apoptosis ≈20%, as evidenced by sub-G1 cells and annexin V-staining cells. Treatment with PG also induced the loss of mitochondrial membrane potential (Δψm) in SNU-484 cells. The intracellular reactive oxygen species (ROS) levels including O·− were significantly increased in PG-treated cells. Furthermore, the depletion of the intracellular glutathione (GSH) content was observed in cells treated with 50 or 80 μM PG. In conclusion, PG inhibited the growth of human gastric cancer SNU-484 cells by inducing cell cycle arrest as well as triggering apoptosis. The changes in ROS and GSH by PG were closely related to apoptosis in SNU-484 cells.

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Copy and paste a formatted citation
Spandidos Publications style
Park WH, Park MN, Han YH and Kim SW: Pyrogallol inhibits the growth of gastric cancer SNU-484 cells via induction of apoptosis. Int J Mol Med 22: 263-268, 2008.
APA
Park, W.H., Park, M.N., Han, Y.H., & Kim, S.W. (2008). Pyrogallol inhibits the growth of gastric cancer SNU-484 cells via induction of apoptosis. International Journal of Molecular Medicine, 22, 263-268. https://doi.org/10.3892/ijmm_00000018
MLA
Park, W. H., Park, M. N., Han, Y. H., Kim, S. W."Pyrogallol inhibits the growth of gastric cancer SNU-484 cells via induction of apoptosis". International Journal of Molecular Medicine 22.2 (2008): 263-268.
Chicago
Park, W. H., Park, M. N., Han, Y. H., Kim, S. W."Pyrogallol inhibits the growth of gastric cancer SNU-484 cells via induction of apoptosis". International Journal of Molecular Medicine 22, no. 2 (2008): 263-268. https://doi.org/10.3892/ijmm_00000018
Copy and paste a formatted citation
x
Spandidos Publications style
Park WH, Park MN, Han YH and Kim SW: Pyrogallol inhibits the growth of gastric cancer SNU-484 cells via induction of apoptosis. Int J Mol Med 22: 263-268, 2008.
APA
Park, W.H., Park, M.N., Han, Y.H., & Kim, S.W. (2008). Pyrogallol inhibits the growth of gastric cancer SNU-484 cells via induction of apoptosis. International Journal of Molecular Medicine, 22, 263-268. https://doi.org/10.3892/ijmm_00000018
MLA
Park, W. H., Park, M. N., Han, Y. H., Kim, S. W."Pyrogallol inhibits the growth of gastric cancer SNU-484 cells via induction of apoptosis". International Journal of Molecular Medicine 22.2 (2008): 263-268.
Chicago
Park, W. H., Park, M. N., Han, Y. H., Kim, S. W."Pyrogallol inhibits the growth of gastric cancer SNU-484 cells via induction of apoptosis". International Journal of Molecular Medicine 22, no. 2 (2008): 263-268. https://doi.org/10.3892/ijmm_00000018
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