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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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November 2008 Volume 22 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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November 2008 Volume 22 Issue 5

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Claudin-1 expression is induced by tumor necrosis factor-α in human pancreatic cancer cells

  • Authors:
    • Jun Kondo
    • Fuyuki Sato
    • Tomomi Kusumi
    • Yang Liu
    • Ohashi Motonari
    • Tatsusuke Sato
    • Hiroshi Kijima

  • View Affiliations / Copyright

    Affiliations: Department of Pathology and Bioscience, Hirosaki University Graduate School of Medicine, Hirosaki 036-8562, Japan
  • Pages: 645-649
    |
    Published online on: November 1, 2008
       https://doi.org/10.3892/ijmm_00000067
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Abstract

Claudin-1 is a membrane protein with four transmembrane domains, that is exclusively localized at cellular tight junctions. Recent studies have reported that claudin-1 plays an important role in cancer invasion and metastasis. However, the significance of claudin-1 in pancreatic cancer is still unknown. In the present study, we investigated the role of claudin-1 expression in pancreatic cancer growth using the PANC-1 human pancreatic cancer cell line. Treatment with tumor necrosis factor-α (TNF-α), an inflammatory cytokine, resulted in increased detection of 89 kDa products of poly-(ADP-ribose) polymerase (PARP), a marker of apoptosis, and decreased PANC-1 cell proliferation by 23%. Expression of claudin-1 was up-regulated by TNF-α in a concentration-dependent manner in PANC-1 cells. PANC-1 cells treated with TNF-α and siRNA against claudin-1 showed a 15% increase in proliferation; i.e. the cells transfected with siRNA against claudin-1 showed resistance to TNF-α-induced apoptosis. These results suggest that claudin-1 expression is responsible for TNF-α-dependent growth signals and the proliferation of pancreatic cancer cells.

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Copy and paste a formatted citation
Spandidos Publications style
Kondo J, Sato F, Kusumi T, Liu Y, Motonari O, Sato T and Kijima H: Claudin-1 expression is induced by tumor necrosis factor-α in human pancreatic cancer cells. Int J Mol Med 22: 645-649, 2008.
APA
Kondo, J., Sato, F., Kusumi, T., Liu, Y., Motonari, O., Sato, T., & Kijima, H. (2008). Claudin-1 expression is induced by tumor necrosis factor-α in human pancreatic cancer cells. International Journal of Molecular Medicine, 22, 645-649. https://doi.org/10.3892/ijmm_00000067
MLA
Kondo, J., Sato, F., Kusumi, T., Liu, Y., Motonari, O., Sato, T., Kijima, H."Claudin-1 expression is induced by tumor necrosis factor-α in human pancreatic cancer cells". International Journal of Molecular Medicine 22.5 (2008): 645-649.
Chicago
Kondo, J., Sato, F., Kusumi, T., Liu, Y., Motonari, O., Sato, T., Kijima, H."Claudin-1 expression is induced by tumor necrosis factor-α in human pancreatic cancer cells". International Journal of Molecular Medicine 22, no. 5 (2008): 645-649. https://doi.org/10.3892/ijmm_00000067
Copy and paste a formatted citation
x
Spandidos Publications style
Kondo J, Sato F, Kusumi T, Liu Y, Motonari O, Sato T and Kijima H: Claudin-1 expression is induced by tumor necrosis factor-α in human pancreatic cancer cells. Int J Mol Med 22: 645-649, 2008.
APA
Kondo, J., Sato, F., Kusumi, T., Liu, Y., Motonari, O., Sato, T., & Kijima, H. (2008). Claudin-1 expression is induced by tumor necrosis factor-α in human pancreatic cancer cells. International Journal of Molecular Medicine, 22, 645-649. https://doi.org/10.3892/ijmm_00000067
MLA
Kondo, J., Sato, F., Kusumi, T., Liu, Y., Motonari, O., Sato, T., Kijima, H."Claudin-1 expression is induced by tumor necrosis factor-α in human pancreatic cancer cells". International Journal of Molecular Medicine 22.5 (2008): 645-649.
Chicago
Kondo, J., Sato, F., Kusumi, T., Liu, Y., Motonari, O., Sato, T., Kijima, H."Claudin-1 expression is induced by tumor necrosis factor-α in human pancreatic cancer cells". International Journal of Molecular Medicine 22, no. 5 (2008): 645-649. https://doi.org/10.3892/ijmm_00000067
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