Lipid peroxides induce early onset of catagen phase in murine hair cycles

  • Authors:
    • Atsushi Naito
    • Tatsuyuki Midorikawa
    • Teruhiko Yoshino
    • Motoyasu Ohdera
  • View Affiliations

  • Published online on: December 1, 2008     https://doi.org/10.3892/ijmm_00000078
  • Pages: 725-729
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Abstract

The precise mechanisms of alopecia, a pathophysiological disorder with negative psychological implications, are unknown. Androgen and hereditary predisposition are major causes, but the condition is also affected by stress, an irregular diet and high levels of sebum secretion. We focused on oxidative stress and analyzed the effect of the lipid peroxides on hair follicles. Our first observation was that the topical application of linolein hydroperoxides, one of the lipid peroxides, lead to the early onset of the catagen phase in murine hair cycles. Furthermore, by using TUNEL staining we found that lipid peroxides induced apoptosis of hair follicle cells. They also induced apoptosis in human epidermal keratinocytes by up-regulating apoptosis-related genes. These results indicated that lipid peroxides, which can cause free radicals, induce the apoptosis of hair follicle cells, and this is followed by early onset of the catagen phase. These observations may provide insight into the mechanisms underlying the development of alopecia in humans.

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December 2008
Volume 22 Issue 6

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Naito A, Midorikawa T, Yoshino T and Ohdera M: Lipid peroxides induce early onset of catagen phase in murine hair cycles. Int J Mol Med 22: 725-729, 2008.
APA
Naito, A., Midorikawa, T., Yoshino, T., & Ohdera, M. (2008). Lipid peroxides induce early onset of catagen phase in murine hair cycles. International Journal of Molecular Medicine, 22, 725-729. https://doi.org/10.3892/ijmm_00000078
MLA
Naito, A., Midorikawa, T., Yoshino, T., Ohdera, M."Lipid peroxides induce early onset of catagen phase in murine hair cycles". International Journal of Molecular Medicine 22.6 (2008): 725-729.
Chicago
Naito, A., Midorikawa, T., Yoshino, T., Ohdera, M."Lipid peroxides induce early onset of catagen phase in murine hair cycles". International Journal of Molecular Medicine 22, no. 6 (2008): 725-729. https://doi.org/10.3892/ijmm_00000078