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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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April 2009 Volume 23 Issue 4

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Article

Association of genetic variants with chronic kidney disease in Japanese individuals with type 2 diabetes mellitus

  • Authors:
    • Tetsuro Yoshida
    • Kimihiko Kato
    • Kiyoshi Yokoi
    • Sachiro Watanabe
    • Norifumi Metoki
    • Hidemi Yoshida
    • Kei Satoh
    • Yukitoshi Aoyagi
    • Yutaka Nishigaki
    • Takao Suzuki
    • Yoshinori Nozawa
    • Yoshiji Yamada

  • View Affiliations / Copyright

    Affiliations: Department of Cardiovascular Medicine, Inabe General Hospital, Inabe, Japan
  • Pages: 529-537
    |
    Published online on: April 1, 2009
       https://doi.org/10.3892/ijmm_00000161
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Abstract

Although diabetes mellitus has been recognized as a risk factor for chronic kidney disease (CKD), genetic factors for predisposition to CKD in individuals with diabetes mellitus remain elucidated. The purpose of the present study was to identify genetic variants that confer susceptibility to CKD among individuals with type 2 diabetes mellitus. The study population comprised 1742 Japanese individuals, including 636 subjects with CKD [estimated glomerular filtration rate (eGFR) <60 ml/min/1.73 m2] and 1106 controls (eGFR ≥60 ml/min/1.73 m2). The genotypes for 24 polymorphisms of 22 candidate genes were determined. An initial screen of allele frequencies by the Chi-square test revealed that four polymorphisms were significantly (false discovery rate <0.05) associated with the prevalence of CKD in individuals with type 2 diabetes mellitus. Subsequent multivariable logistic regression analysis with adjustment for covariates as well as a stepwise forward selection procedure revealed that the 8733T↷C polymorphism of ALOX5AP (rs3803278), the C↷T (Ser532Leu) polymorphism of IRAK1 (rs1059703), and the 2445G↷A (Ala54Thr) polymorphism of FABP2 (rs1799883) were significantly (P<0.05) associated with the prevalence of CKD. Our results suggest that ALOX5AP, IRAK1, and FABP2 are susceptibility loci for CKD among Japanese individuals with type 2 diabetes mellitus.

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Copy and paste a formatted citation
Spandidos Publications style
Yoshida T, Kato K, Yokoi K, Watanabe S, Metoki N, Yoshida H, Satoh K, Aoyagi Y, Nishigaki Y, Suzuki T, Suzuki T, et al: Association of genetic variants with chronic kidney disease in Japanese individuals with type 2 diabetes mellitus. Int J Mol Med 23: 529-537, 2009.
APA
Yoshida, T., Kato, K., Yokoi, K., Watanabe, S., Metoki, N., Yoshida, H. ... Yamada, Y. (2009). Association of genetic variants with chronic kidney disease in Japanese individuals with type 2 diabetes mellitus. International Journal of Molecular Medicine, 23, 529-537. https://doi.org/10.3892/ijmm_00000161
MLA
Yoshida, T., Kato, K., Yokoi, K., Watanabe, S., Metoki, N., Yoshida, H., Satoh, K., Aoyagi, Y., Nishigaki, Y., Suzuki, T., Nozawa, Y., Yamada, Y."Association of genetic variants with chronic kidney disease in Japanese individuals with type 2 diabetes mellitus". International Journal of Molecular Medicine 23.4 (2009): 529-537.
Chicago
Yoshida, T., Kato, K., Yokoi, K., Watanabe, S., Metoki, N., Yoshida, H., Satoh, K., Aoyagi, Y., Nishigaki, Y., Suzuki, T., Nozawa, Y., Yamada, Y."Association of genetic variants with chronic kidney disease in Japanese individuals with type 2 diabetes mellitus". International Journal of Molecular Medicine 23, no. 4 (2009): 529-537. https://doi.org/10.3892/ijmm_00000161
Copy and paste a formatted citation
x
Spandidos Publications style
Yoshida T, Kato K, Yokoi K, Watanabe S, Metoki N, Yoshida H, Satoh K, Aoyagi Y, Nishigaki Y, Suzuki T, Suzuki T, et al: Association of genetic variants with chronic kidney disease in Japanese individuals with type 2 diabetes mellitus. Int J Mol Med 23: 529-537, 2009.
APA
Yoshida, T., Kato, K., Yokoi, K., Watanabe, S., Metoki, N., Yoshida, H. ... Yamada, Y. (2009). Association of genetic variants with chronic kidney disease in Japanese individuals with type 2 diabetes mellitus. International Journal of Molecular Medicine, 23, 529-537. https://doi.org/10.3892/ijmm_00000161
MLA
Yoshida, T., Kato, K., Yokoi, K., Watanabe, S., Metoki, N., Yoshida, H., Satoh, K., Aoyagi, Y., Nishigaki, Y., Suzuki, T., Nozawa, Y., Yamada, Y."Association of genetic variants with chronic kidney disease in Japanese individuals with type 2 diabetes mellitus". International Journal of Molecular Medicine 23.4 (2009): 529-537.
Chicago
Yoshida, T., Kato, K., Yokoi, K., Watanabe, S., Metoki, N., Yoshida, H., Satoh, K., Aoyagi, Y., Nishigaki, Y., Suzuki, T., Nozawa, Y., Yamada, Y."Association of genetic variants with chronic kidney disease in Japanese individuals with type 2 diabetes mellitus". International Journal of Molecular Medicine 23, no. 4 (2009): 529-537. https://doi.org/10.3892/ijmm_00000161
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