ERK activation induced by selenium treatment significantly downregulates β/γ-secretase activity and Tau phosphorylation in the transgenic rat overexpressing human selenoprotein M

  • Authors:
    • Su Y. Yim
    • Kab R. Chae
    • Sun B. Shim
    • Jin T. Hong
    • Jung Y. park
    • Chung Y. Lee
    • Hong J. Son
    • Yhun Y. sheen
    • Dae Y. Hwang
  • View Affiliations

  • Published online on: July 1, 2009     https://doi.org/10.3892/ijmm_00000211
  • Pages: 91-96
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Abstract

Selenium reportedly contribute to the modulation process of protein phosphorylation to regulate various cellular functions including growth, differentiation, proliferation and development. The aim of this study was to investigate whether selenium and Selenoprotein M (SelM) affects the mechanism of Alzheimer's disease. To achieve this, we determined the change of the MAPK pathway, secretase activity, and Tau phosphorylation in the transgenic rat overexpressing human selenoprotein M. Based on these results, we concluded that, i) CMV/GFP-hSelM Tg rats showed a high activity level of antioxidant enzyme in the brain tissues, ii) in response to selenium treatment, the ERK signaling pathway was significantly increased in Tg rats, but did not change in wild-type rats, iii) the activation of the ERK pathway by selenium treatment and SelM overexpression induced the inhibition of the α/γ-secretase activity related to the protection of Aβ-42 production, iv) the activation of the ERK pathway by selenium treatment and SelM overexpression inhibited the phosphorylation in several sites of Tau protein. Therefore, these results provide strong evidence that selenium treatment and SelM activate the ERK pathway to attenuate α/γ-secretase-mediated proteolysis and Tau phosphorylation to protect brain function.

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July 2009
Volume 24 Issue 1

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Yim SY, Chae KR, Shim SB, Hong JT, park JY, Lee CY, Son HJ, sheen YY and Hwang DY: ERK activation induced by selenium treatment significantly downregulates β/γ-secretase activity and Tau phosphorylation in the transgenic rat overexpressing human selenoprotein M. Int J Mol Med 24: 91-96, 2009.
APA
Yim, S.Y., Chae, K.R., Shim, S.B., Hong, J.T., park, J.Y., Lee, C.Y. ... Hwang, D.Y. (2009). ERK activation induced by selenium treatment significantly downregulates β/γ-secretase activity and Tau phosphorylation in the transgenic rat overexpressing human selenoprotein M. International Journal of Molecular Medicine, 24, 91-96. https://doi.org/10.3892/ijmm_00000211
MLA
Yim, S. Y., Chae, K. R., Shim, S. B., Hong, J. T., park, J. Y., Lee, C. Y., Son, H. J., sheen, Y. Y., Hwang, D. Y."ERK activation induced by selenium treatment significantly downregulates β/γ-secretase activity and Tau phosphorylation in the transgenic rat overexpressing human selenoprotein M". International Journal of Molecular Medicine 24.1 (2009): 91-96.
Chicago
Yim, S. Y., Chae, K. R., Shim, S. B., Hong, J. T., park, J. Y., Lee, C. Y., Son, H. J., sheen, Y. Y., Hwang, D. Y."ERK activation induced by selenium treatment significantly downregulates β/γ-secretase activity and Tau phosphorylation in the transgenic rat overexpressing human selenoprotein M". International Journal of Molecular Medicine 24, no. 1 (2009): 91-96. https://doi.org/10.3892/ijmm_00000211