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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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September 2009 Volume 24 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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September 2009 Volume 24 Issue 3

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Article

In vitro and in vivo antimicrobial activity of water-soluble chitosan oligosaccharides against Vibrio vulnificus

  • Authors:
    • Byung Cheol Lee
    • Myun Soo Kim
    • Sang Ho Choi
    • Kwang Yoon Kim
    • Tae Sung Kim

  • View Affiliations / Copyright

    Affiliations: School of Life Sciences and Biotechnology, Korea University, Seoul 136-701, Republic of Korea
  • Pages: 327-333
    |
    Published online on: September 1, 2009
       https://doi.org/10.3892/ijmm_00000236
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Abstract

Vibrio vulnificus is a Gram-negative bacterium that induces severely rapid pathological progress. In this study, we evaluated the antibacterial activity of two water-soluble chitosan oligosaccharides, COS A (MW, 10,000 Da) and COS B (MW, 1,000 Da), from 90-95% deacetylated chitosan, against V. vulnificus in vitro and in vivo. Treatment with COS A resulted in significantly higher suppressive effects on the growth of V. vulnificus than treatment with COS B. The growth of V. vulnificus was inhibited within 1 h of treatment with water-soluble COS A in concentrations ranging from 0.5 to 10 mg/ml. Additionally, treatment with COS A completely inhibited V. vulnificus-induced cytotoxicity in human intestinal epithelial INT-407 cells, while COS B did not. Furthermore, the administration of COS A (0.1-0.5 mg per mouse) significantly increased the survival period of V. vulnificus-infected mice. The number of viable V. vulnificus in the spleen, liver, small intestine, and blood was significantly lower in COS A-treated mice than in untreated mice. Here, we clearly demonstrate that COS A is a potential agent for the prevention and treatment of infection with V. vulnificus.

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Copy and paste a formatted citation
Spandidos Publications style
Lee BC, Kim MS, Choi SH, Kim KY and Kim TS: In vitro and in vivo antimicrobial activity of water-soluble chitosan oligosaccharides against Vibrio vulnificus. Int J Mol Med 24: 327-333, 2009.
APA
Lee, B.C., Kim, M.S., Choi, S.H., Kim, K.Y., & Kim, T.S. (2009). In vitro and in vivo antimicrobial activity of water-soluble chitosan oligosaccharides against Vibrio vulnificus. International Journal of Molecular Medicine, 24, 327-333. https://doi.org/10.3892/ijmm_00000236
MLA
Lee, B. C., Kim, M. S., Choi, S. H., Kim, K. Y., Kim, T. S."In vitro and in vivo antimicrobial activity of water-soluble chitosan oligosaccharides against Vibrio vulnificus". International Journal of Molecular Medicine 24.3 (2009): 327-333.
Chicago
Lee, B. C., Kim, M. S., Choi, S. H., Kim, K. Y., Kim, T. S."In vitro and in vivo antimicrobial activity of water-soluble chitosan oligosaccharides against Vibrio vulnificus". International Journal of Molecular Medicine 24, no. 3 (2009): 327-333. https://doi.org/10.3892/ijmm_00000236
Copy and paste a formatted citation
x
Spandidos Publications style
Lee BC, Kim MS, Choi SH, Kim KY and Kim TS: In vitro and in vivo antimicrobial activity of water-soluble chitosan oligosaccharides against Vibrio vulnificus. Int J Mol Med 24: 327-333, 2009.
APA
Lee, B.C., Kim, M.S., Choi, S.H., Kim, K.Y., & Kim, T.S. (2009). In vitro and in vivo antimicrobial activity of water-soluble chitosan oligosaccharides against Vibrio vulnificus. International Journal of Molecular Medicine, 24, 327-333. https://doi.org/10.3892/ijmm_00000236
MLA
Lee, B. C., Kim, M. S., Choi, S. H., Kim, K. Y., Kim, T. S."In vitro and in vivo antimicrobial activity of water-soluble chitosan oligosaccharides against Vibrio vulnificus". International Journal of Molecular Medicine 24.3 (2009): 327-333.
Chicago
Lee, B. C., Kim, M. S., Choi, S. H., Kim, K. Y., Kim, T. S."In vitro and in vivo antimicrobial activity of water-soluble chitosan oligosaccharides against Vibrio vulnificus". International Journal of Molecular Medicine 24, no. 3 (2009): 327-333. https://doi.org/10.3892/ijmm_00000236
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