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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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October 2009 Volume 24 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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October 2009 Volume 24 Issue 4

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Article

Low levels of soluble CD1d protein alters NKT cell function in patients with rheumatoid arthritis

  • Authors:
    • Seiji Segawa
    • Daisuke Goto
    • Yohei Yoshiga
    • Taichi Hayashi
    • Isao Matsumoto
    • Satoshi Ito
    • Takayuki Sumida

  • View Affiliations / Copyright

    Affiliations: Division of Clinical Immunology, Doctoral Program in Clinical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Japan
  • Pages: 481-486
    |
    Published online on: October 1, 2009
       https://doi.org/10.3892/ijmm_00000256
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Abstract

CD1d molecules on the cell surface play a critical role in the presentation of glycolipid antigens to natural killer T (NKT) cells. We previously showed that the human CD1d gene has 8 splice variants, one of which is a soluble form lacking the β2-m and transmembrane domains. This study focused on soluble CD1d (sCD1d) by generating recombinant sCD1d proteins and assaying them in plasma using a newly established ELISA method. The amount of sCD1d proteins in plasma was significantly decreased in rheumatoid arthritis (RA) patients (55.2±13.3 years, mean ±SD) compared with healthy donors (31.2±7.4 years). Plasma sCD1d protein levels correlated with the number of NKT cells (TCR Vα24+ Vβ11+CD3+) in peripheral blood mononuclear cells (r2=0.061). Furthermore, sCD1d proteins induced IFN-γ production from NKT cells, but neither IL-4 nor IL-10. These findings suggest that the low plasma levels of sCD1d protein in RA patients reduce the number and thus activation of peripheral NKT cells. It is therefore hypothesized that sCD1d stimulates NKT cells and low plasma sCD1d levels in RA reflect a pathogenic mechanism associated with a decrease in NKT cells.

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Copy and paste a formatted citation
Spandidos Publications style
Segawa S, Goto D, Yoshiga Y, Hayashi T, Matsumoto I, Ito S and Sumida T: Low levels of soluble CD1d protein alters NKT cell function in patients with rheumatoid arthritis. Int J Mol Med 24: 481-486, 2009.
APA
Segawa, S., Goto, D., Yoshiga, Y., Hayashi, T., Matsumoto, I., Ito, S., & Sumida, T. (2009). Low levels of soluble CD1d protein alters NKT cell function in patients with rheumatoid arthritis. International Journal of Molecular Medicine, 24, 481-486. https://doi.org/10.3892/ijmm_00000256
MLA
Segawa, S., Goto, D., Yoshiga, Y., Hayashi, T., Matsumoto, I., Ito, S., Sumida, T."Low levels of soluble CD1d protein alters NKT cell function in patients with rheumatoid arthritis". International Journal of Molecular Medicine 24.4 (2009): 481-486.
Chicago
Segawa, S., Goto, D., Yoshiga, Y., Hayashi, T., Matsumoto, I., Ito, S., Sumida, T."Low levels of soluble CD1d protein alters NKT cell function in patients with rheumatoid arthritis". International Journal of Molecular Medicine 24, no. 4 (2009): 481-486. https://doi.org/10.3892/ijmm_00000256
Copy and paste a formatted citation
x
Spandidos Publications style
Segawa S, Goto D, Yoshiga Y, Hayashi T, Matsumoto I, Ito S and Sumida T: Low levels of soluble CD1d protein alters NKT cell function in patients with rheumatoid arthritis. Int J Mol Med 24: 481-486, 2009.
APA
Segawa, S., Goto, D., Yoshiga, Y., Hayashi, T., Matsumoto, I., Ito, S., & Sumida, T. (2009). Low levels of soluble CD1d protein alters NKT cell function in patients with rheumatoid arthritis. International Journal of Molecular Medicine, 24, 481-486. https://doi.org/10.3892/ijmm_00000256
MLA
Segawa, S., Goto, D., Yoshiga, Y., Hayashi, T., Matsumoto, I., Ito, S., Sumida, T."Low levels of soluble CD1d protein alters NKT cell function in patients with rheumatoid arthritis". International Journal of Molecular Medicine 24.4 (2009): 481-486.
Chicago
Segawa, S., Goto, D., Yoshiga, Y., Hayashi, T., Matsumoto, I., Ito, S., Sumida, T."Low levels of soluble CD1d protein alters NKT cell function in patients with rheumatoid arthritis". International Journal of Molecular Medicine 24, no. 4 (2009): 481-486. https://doi.org/10.3892/ijmm_00000256
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