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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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December 2009 Volume 24 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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December 2009 Volume 24 Issue 6

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Article Open Access

Neuronal and BBB damage induced by sera from patients with secondary progressive multiple sclerosis

  • Authors:
    • Patrizia Proia
    • Gabriella Schiera
    • Giuseppe Salemi
    • Paolo Ragonese
    • Giovanni Savettieri
    • Italia Di Liegro

  • View Affiliations / Copyright

    Affiliations: Dipartimento di Studi Giuridici, Economici, Biomedici, Psicosociopedagogici delle Scienze Motorie e Sportive, Università degli Studi di Palermo, Palermo, Italy
  • Pages: 743-747
    |
    Published online on: December 1, 2009
       https://doi.org/10.3892/ijmm_00000287
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Abstract

An important component of the pathogenic process of multiple sclerosis (MS) is the blood-brain barrier (BBB) damage. We recently set an in vitro model of BBB, based on a three-cell-type co-culture system, in which rat neurons and astrocytes synergistically induce brain capillary endothelial cells to form a monolayer with permeability properties resembling those of the physiological BBB. Herein we report that the serum from patients with secondary progressive multiple sclerosis (SPMS) has a damaging effect on isolated neurons. This finding suggests that neuronal damaging in MS could be a primary event and not only secondary to myelin damage, as generally assumed. SPMS serum affects the permeability of the BBB model, as indicated by the decrease of the transendothelial electrical resistance (TEER). Moreover, as shown by both immunofluorescence and Western blot analyses, BBB breaking is accompanied by a decrease of the synthesis as well as the peripheral localization of occludin, a structural protein of the tight junctions that are responsible for BBB properties.

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Copy and paste a formatted citation
Spandidos Publications style
Proia P, Schiera G, Salemi G, Ragonese P, Savettieri G and Di Liegro I: Neuronal and BBB damage induced by sera from patients with secondary progressive multiple sclerosis . Int J Mol Med 24: 743-747, 2009.
APA
Proia, P., Schiera, G., Salemi, G., Ragonese, P., Savettieri, G., & Di Liegro, I. (2009). Neuronal and BBB damage induced by sera from patients with secondary progressive multiple sclerosis . International Journal of Molecular Medicine, 24, 743-747. https://doi.org/10.3892/ijmm_00000287
MLA
Proia, P., Schiera, G., Salemi, G., Ragonese, P., Savettieri, G., Di Liegro, I."Neuronal and BBB damage induced by sera from patients with secondary progressive multiple sclerosis ". International Journal of Molecular Medicine 24.6 (2009): 743-747.
Chicago
Proia, P., Schiera, G., Salemi, G., Ragonese, P., Savettieri, G., Di Liegro, I."Neuronal and BBB damage induced by sera from patients with secondary progressive multiple sclerosis ". International Journal of Molecular Medicine 24, no. 6 (2009): 743-747. https://doi.org/10.3892/ijmm_00000287
Copy and paste a formatted citation
x
Spandidos Publications style
Proia P, Schiera G, Salemi G, Ragonese P, Savettieri G and Di Liegro I: Neuronal and BBB damage induced by sera from patients with secondary progressive multiple sclerosis . Int J Mol Med 24: 743-747, 2009.
APA
Proia, P., Schiera, G., Salemi, G., Ragonese, P., Savettieri, G., & Di Liegro, I. (2009). Neuronal and BBB damage induced by sera from patients with secondary progressive multiple sclerosis . International Journal of Molecular Medicine, 24, 743-747. https://doi.org/10.3892/ijmm_00000287
MLA
Proia, P., Schiera, G., Salemi, G., Ragonese, P., Savettieri, G., Di Liegro, I."Neuronal and BBB damage induced by sera from patients with secondary progressive multiple sclerosis ". International Journal of Molecular Medicine 24.6 (2009): 743-747.
Chicago
Proia, P., Schiera, G., Salemi, G., Ragonese, P., Savettieri, G., Di Liegro, I."Neuronal and BBB damage induced by sera from patients with secondary progressive multiple sclerosis ". International Journal of Molecular Medicine 24, no. 6 (2009): 743-747. https://doi.org/10.3892/ijmm_00000287
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