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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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March 2010 Volume 25 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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March 2010 Volume 25 Issue 3

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Article

Onion extract and quercetin induce matrix metalloproteinase-1 in vitro and in vivo

  • Authors:
    • Jae-We Cho
    • Sun-Young Cho
    • Seong-Ryong Lee
    • Kyu-Suk Lee

  • View Affiliations / Copyright

    Affiliations: Department of Dermatology, School of Medicine, Daegu 700-712, Korea
  • Pages: 347-352
    |
    Published online on: March 1, 2010
       https://doi.org/10.3892/ijmm_00000351
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Abstract

A scar is usually developed by an imbalance of collagen synthesis and degradation. It is believed that the flavonoids (quercetin and kaempferol) in onion extract play a role in reducing scar formation through inhibition of fibroblast activities. Even though several commercial products are composed of onion extract, the precise molecular mechanisms of onion extract in reduction of scar formation in skin are still largely unknown. In this study we investigated the effect both of onion extract and quercetin on the proliferation of fibroblasts, expression of type I collagen and matrix metalloproteinase-1 (MMP-1). Our data show that proliferation rates of fibroblasts were decreased in a dose-dependent manner of the onion extract and quercetin. The expression of type I collagen was not markedly changed by the onion extract and quercetin. Interestingly, the expression of MMP-1 was markedly increased by both onion extract and quercetin in vitro and in vivo. Thus, our data indicate that onion extract and quercetin play a role in the anti-scar effect in skin through up-regulation of MMP-1 expression, implying this agent is a promising material for reducing scar formation.

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Copy and paste a formatted citation
Spandidos Publications style
Cho J, Cho S, Lee S and Lee K: Onion extract and quercetin induce matrix metalloproteinase-1 in vitro and in vivo. Int J Mol Med 25: 347-352, 2010.
APA
Cho, J., Cho, S., Lee, S., & Lee, K. (2010). Onion extract and quercetin induce matrix metalloproteinase-1 in vitro and in vivo. International Journal of Molecular Medicine, 25, 347-352. https://doi.org/10.3892/ijmm_00000351
MLA
Cho, J., Cho, S., Lee, S., Lee, K."Onion extract and quercetin induce matrix metalloproteinase-1 in vitro and in vivo". International Journal of Molecular Medicine 25.3 (2010): 347-352.
Chicago
Cho, J., Cho, S., Lee, S., Lee, K."Onion extract and quercetin induce matrix metalloproteinase-1 in vitro and in vivo". International Journal of Molecular Medicine 25, no. 3 (2010): 347-352. https://doi.org/10.3892/ijmm_00000351
Copy and paste a formatted citation
x
Spandidos Publications style
Cho J, Cho S, Lee S and Lee K: Onion extract and quercetin induce matrix metalloproteinase-1 in vitro and in vivo. Int J Mol Med 25: 347-352, 2010.
APA
Cho, J., Cho, S., Lee, S., & Lee, K. (2010). Onion extract and quercetin induce matrix metalloproteinase-1 in vitro and in vivo. International Journal of Molecular Medicine, 25, 347-352. https://doi.org/10.3892/ijmm_00000351
MLA
Cho, J., Cho, S., Lee, S., Lee, K."Onion extract and quercetin induce matrix metalloproteinase-1 in vitro and in vivo". International Journal of Molecular Medicine 25.3 (2010): 347-352.
Chicago
Cho, J., Cho, S., Lee, S., Lee, K."Onion extract and quercetin induce matrix metalloproteinase-1 in vitro and in vivo". International Journal of Molecular Medicine 25, no. 3 (2010): 347-352. https://doi.org/10.3892/ijmm_00000351
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