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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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March 2010 Volume 25 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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March 2010 Volume 25 Issue 3

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Article

Celastrol and an EGCG pro-drug exhibit potent chemosensitizing activity in human leukemia cells

  • Authors:
    • Andrew Davenport
    • Michael Frezza
    • Min Shen
    • Yubin Ge
    • Congde Huo
    • Tak Hang Chan
    • Q. Ping Dou

  • View Affiliations / Copyright

    Affiliations: The Prevention Program, Barbara Ann Karmanos Cancer Institute, Department of Pathology, Wayne State University School of Medicine, Detroit, MI, USA
  • Pages: 465-470
    |
    Published online on: March 1, 2010
       https://doi.org/10.3892/ijmm_00000366
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Abstract

Chemotherapy remains the staple of treatment for many types of leukemia. Despite the positive impact on extending overall survival in patients with hematological malignancies, new treatment strategies are needed to reduce the nonspecific toxicity and improve the efficacy of treatment. Celastrol, derived from the ‘Thunder God Vine’ and Pro-EGCG, a pre-drug version of green tea polyphenol EGCG have shown potent biological activity in vitro and in vivo. Whether these natural products augment the efficacy of conventional chemotherapy in the treatment of leukemia cells has yet to be demonstrated. Here we demonstrate that these natural products could sensitize the effect of chemotherapy in both K-562 and Jurkat T human leukemia cells. Accordingly, this potent biological activity was associated with increased levels of leukemia cell killing, caspase 3 activation, and poly(ADP-ribose) polymerase cleavage. Furthermore, the higher levels of apoptotic indices were associated with decreased levels of Bcr-Abl oncoprotein in K-562 cells. Taken together, our findings present a compelling rationale for the development of combination strategies using natural products in the treatment of hematological malignancies.

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Copy and paste a formatted citation
Spandidos Publications style
Davenport A, Frezza M, Shen M, Ge Y, Huo C, Chan TH and Dou QP: Celastrol and an EGCG pro-drug exhibit potent chemosensitizing activity in human leukemia cells. Int J Mol Med 25: 465-470, 2010.
APA
Davenport, A., Frezza, M., Shen, M., Ge, Y., Huo, C., Chan, T.H., & Dou, Q.P. (2010). Celastrol and an EGCG pro-drug exhibit potent chemosensitizing activity in human leukemia cells. International Journal of Molecular Medicine, 25, 465-470. https://doi.org/10.3892/ijmm_00000366
MLA
Davenport, A., Frezza, M., Shen, M., Ge, Y., Huo, C., Chan, T. H., Dou, Q. P."Celastrol and an EGCG pro-drug exhibit potent chemosensitizing activity in human leukemia cells". International Journal of Molecular Medicine 25.3 (2010): 465-470.
Chicago
Davenport, A., Frezza, M., Shen, M., Ge, Y., Huo, C., Chan, T. H., Dou, Q. P."Celastrol and an EGCG pro-drug exhibit potent chemosensitizing activity in human leukemia cells". International Journal of Molecular Medicine 25, no. 3 (2010): 465-470. https://doi.org/10.3892/ijmm_00000366
Copy and paste a formatted citation
x
Spandidos Publications style
Davenport A, Frezza M, Shen M, Ge Y, Huo C, Chan TH and Dou QP: Celastrol and an EGCG pro-drug exhibit potent chemosensitizing activity in human leukemia cells. Int J Mol Med 25: 465-470, 2010.
APA
Davenport, A., Frezza, M., Shen, M., Ge, Y., Huo, C., Chan, T.H., & Dou, Q.P. (2010). Celastrol and an EGCG pro-drug exhibit potent chemosensitizing activity in human leukemia cells. International Journal of Molecular Medicine, 25, 465-470. https://doi.org/10.3892/ijmm_00000366
MLA
Davenport, A., Frezza, M., Shen, M., Ge, Y., Huo, C., Chan, T. H., Dou, Q. P."Celastrol and an EGCG pro-drug exhibit potent chemosensitizing activity in human leukemia cells". International Journal of Molecular Medicine 25.3 (2010): 465-470.
Chicago
Davenport, A., Frezza, M., Shen, M., Ge, Y., Huo, C., Chan, T. H., Dou, Q. P."Celastrol and an EGCG pro-drug exhibit potent chemosensitizing activity in human leukemia cells". International Journal of Molecular Medicine 25, no. 3 (2010): 465-470. https://doi.org/10.3892/ijmm_00000366
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