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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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May 2010 Volume 25 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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May 2010 Volume 25 Issue 5

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Article

Small Rho GTPase Rac1 determines human epidermal stem cell fate in vitro

  • Authors:
    • Linlin Chai
    • Chuan Cao
    • Sheng Bi
    • Xia Dai
    • Lu Gan
    • Rui Guo
    • Shirong Li

  • View Affiliations / Copyright

    Affiliations: Department of Plastic and Reconstructive Surgery, Southwestern Hospital, Third Military Medical University, Chongqing 400038, P.R. China
  • Pages: 723-727
    |
    Published online on: May 1, 2010
       https://doi.org/10.3892/ijmm_00000397
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Abstract

Epidermal stem cells (ESCs) are essential not only for tissue homeostasis but also for skin to respond to insults, but the mechanisms of stem cell regulation are unknown. To investigate the function of Rac1 in ESC development, we introduced either the dominant negative isoform or constitutively the active mutant of Rac1 in cultured human ESCs by using a retroviral vector and then analyzed the consequences. Upon activation, Rac1 increased surface α6/β1 integrin levels and promoted colony forming efficiency of ESCs. Conversely, dominant negative Rac1 caused a progressive reduction in growth rate, an inhibition of adhesiveness and a marked stimulation of terminal differentiation, without any effect on the cell cycle. These results were consistent with the role of Rac1 in determining the fate of ESCs by controlling their exit from the stem cell compartment. Our results reveal a novel biological role for Rac1 and provide new insights into the mechanism regulating ESCs.

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Copy and paste a formatted citation
Spandidos Publications style
Chai L, Cao C, Bi S, Dai X, Gan L, Guo R and Li S: Small Rho GTPase Rac1 determines human epidermal stem cell fate in vitro. Int J Mol Med 25: 723-727, 2010.
APA
Chai, L., Cao, C., Bi, S., Dai, X., Gan, L., Guo, R., & Li, S. (2010). Small Rho GTPase Rac1 determines human epidermal stem cell fate in vitro. International Journal of Molecular Medicine, 25, 723-727. https://doi.org/10.3892/ijmm_00000397
MLA
Chai, L., Cao, C., Bi, S., Dai, X., Gan, L., Guo, R., Li, S."Small Rho GTPase Rac1 determines human epidermal stem cell fate in vitro". International Journal of Molecular Medicine 25.5 (2010): 723-727.
Chicago
Chai, L., Cao, C., Bi, S., Dai, X., Gan, L., Guo, R., Li, S."Small Rho GTPase Rac1 determines human epidermal stem cell fate in vitro". International Journal of Molecular Medicine 25, no. 5 (2010): 723-727. https://doi.org/10.3892/ijmm_00000397
Copy and paste a formatted citation
x
Spandidos Publications style
Chai L, Cao C, Bi S, Dai X, Gan L, Guo R and Li S: Small Rho GTPase Rac1 determines human epidermal stem cell fate in vitro. Int J Mol Med 25: 723-727, 2010.
APA
Chai, L., Cao, C., Bi, S., Dai, X., Gan, L., Guo, R., & Li, S. (2010). Small Rho GTPase Rac1 determines human epidermal stem cell fate in vitro. International Journal of Molecular Medicine, 25, 723-727. https://doi.org/10.3892/ijmm_00000397
MLA
Chai, L., Cao, C., Bi, S., Dai, X., Gan, L., Guo, R., Li, S."Small Rho GTPase Rac1 determines human epidermal stem cell fate in vitro". International Journal of Molecular Medicine 25.5 (2010): 723-727.
Chicago
Chai, L., Cao, C., Bi, S., Dai, X., Gan, L., Guo, R., Li, S."Small Rho GTPase Rac1 determines human epidermal stem cell fate in vitro". International Journal of Molecular Medicine 25, no. 5 (2010): 723-727. https://doi.org/10.3892/ijmm_00000397
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