Linkage and association study of discoidin domain receptor 1 as a novel susceptibility gene for childhood IgA nephropathy

Hahn,Won-Ho; Suh,Jin-Soon; Cho,Byoung-Soo; Kim,Sung-Do

doi:10.3892/ijmm_00000405

May 2010 Volume 25 Issue 5

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May 2010 Volume 25 Issue 5

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Article

Linkage and association study of discoidin domain receptor 1 as a novel susceptibility gene for childhood IgA nephropathy

Authors:
- Won-Ho Hahn
- Jin-Soon Suh
- Byoung-Soo Cho
- Sung-Do Kim
View Affiliations / Copyright

Affiliations: Department of Pediatrics, East West Kidney Diseases Research Institute, School of Medicine, Kyung Hee University, Seoul 130-701, Korea
Pages: 785-791
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Published online on: May 1, 2010

https://doi.org/10.3892/ijmm_00000405
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Abstract

In several experimental studies, it has been suggested that discoidin domain receptor 1 (DDR1) plays an important role in the regulation of mesangial proliferation, glomerular basement membrane thickening, renal fibrosis, and in the development of inflammation in several tissue types, including renal tissues. The present study was conducted to investigate the association between single nucleotide polymorphisms (SNPs) of the DDR1 gene and childhood IgA nephropathy (IgAN). The genotyping data of 180 childhood IgAN patients and 336 controls showed significant differences in the frequency of rs1264319 (dominant model, P=0.040). Subgroup analysis revealed that development of proteinuria (>4 and ≤4 mg/m2/h; n=131 and 49) was significantly associated with rs2267641 (codominant model, P=0.004; dominant, P=0.024; recessive, P=0.010) and rs9468844 (codominant model, P=0.003; dominant, P=0.017; recessive, P=0.012). Furthermore, rs1264319 frequencies were significantly different in those with pathologically mild and advanced disease subgroups (n=162 and 18; codominant and dominant model, P=0.022). Our results suggest that DDR1 gene is associated with increased susceptibility, pathological advancement, and the development of proteinuria in childhood IgAN.

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Linkage and association study of discoidin domain receptor 1 as a novel susceptibility gene for childhood IgA nephropathy

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Abstract

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