The Kringle-2 domain of tissue plasminogen activator significantly reduces mortality and brain infarction in middle cerebral artery occlusion rats

  • Authors:
    • Haitao Zhang
    • Feng Bi
    • Chunlan Xiao
    • Jianxia Liu
    • Zhixia Wang
    • Jian-Ning Liu
    • Jing Zhang
  • View Affiliations

  • Published online on: August 1, 2010     https://doi.org/10.3892/ijmm_00000456
  • Pages: 225-230
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Abstract

Tissue plasminogen activator (TPA) showed brain-protective activity within the first 15 min after cerebral ischemia in rats. To understand its molecular mechanism, TPA derivates were intracerebroventricularly administered at 15 min before, and 15, 90, 120 min after middle cerebral artery occlusion (MCAO) in rats. The reduction in mortality and cerebral infarction at 24 h was seen only with TPA administered at 15 min after MCAO. The down-regulation of endogenous TPA by the intracerebroventricular injection of TPA was found to be responsible for the protective effect on the integrity of blood-brain barrier after MCAO, as well as for the reduction in mortality and cerebral infarction. Moreover, for the first time we have found that the Kringle-2 domain is essential for the brain-protective activity of TPA.

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August 2010
Volume 26 Issue 2

Print ISSN: 1107-3756
Online ISSN:1791-244X

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APA
Zhang, H., Bi, F., Xiao, C., Liu, J., Wang, Z., Liu, J., & Zhang, J. (2010). The Kringle-2 domain of tissue plasminogen activator significantly reduces mortality and brain infarction in middle cerebral artery occlusion rats. International Journal of Molecular Medicine, 26, 225-230. https://doi.org/10.3892/ijmm_00000456
MLA
Zhang, H., Bi, F., Xiao, C., Liu, J., Wang, Z., Liu, J., Zhang, J."The Kringle-2 domain of tissue plasminogen activator significantly reduces mortality and brain infarction in middle cerebral artery occlusion rats". International Journal of Molecular Medicine 26.2 (2010): 225-230.
Chicago
Zhang, H., Bi, F., Xiao, C., Liu, J., Wang, Z., Liu, J., Zhang, J."The Kringle-2 domain of tissue plasminogen activator significantly reduces mortality and brain infarction in middle cerebral artery occlusion rats". International Journal of Molecular Medicine 26, no. 2 (2010): 225-230. https://doi.org/10.3892/ijmm_00000456