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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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August 2010 Volume 26 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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August 2010 Volume 26 Issue 2

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Article

Trans-Zeatin attenuates ultraviolet induced down-regulation of aquaporin-3 in cultured human skin keratinocytes

  • Authors:
    • Chao Ji
    • Yanli Yang
    • Bo Yang
    • Jiping Xia
    • Weiling Sun
    • Zhonglan Su
    • Liting Yu
    • Shijun Shan
    • Shaoheng He
    • Lei Cheng
    • Yinsheng Wan
    • Zhigang Bi

  • View Affiliations / Copyright

    Affiliations: Department of Dermatology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu, P.R. China
  • Pages: 257-263
    |
    Published online on: August 1, 2010
       https://doi.org/10.3892/ijmm_00000460
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Abstract

Solar ultraviolet (UV) irradiation is one of the most significant extrinsic factors contributing to skin photoaging. One major characteristic of photoaging induced by UV is water loss of the skin. Water movement across the plasma membrane can occur via two pathways: by diffusion through the lipid bilayer and by membrane-inserted water channels (aquaporins). In this study we demonstrate that UV induces aquaporin-3 (AQP3) downregulation in cultured keratinocytes (HaCaT cells). PD98059 and U0126, MEK/ERK inhibitors, inhibit UV-induced AQP3 loss. Trans-Zeatin (tZ), which alone induces AQP3 expression, attenuates UV-induced loss of AQP3. We found that tZ inhibits UV-induced MEK/ERK activation; the latter serves as the key signal pathway mediating UV-induced AQP3 loss. Using specific AQP3 siRNA knockdown, we found AQP3 is involved in wound healing in human skin keratinocytes. Loss-of-AQP3-mediated delayed wound healing in UV-radiated skin keratinocytes is attenuated by tZ pretreatment. tZ pretreatment also attenuates UV-induced decreased water permeability in HaCaT cells. We concluded that UV radiation downregulates AQP3 in HaCaT cells. MEK/ERK activation is involved in this process. tZ treatment attenuates UV-induced AQP3 loss, in vitro wound healing delay and water permeability decrease. This work provides a new explanation for the anti-photoaging potential of tZ.

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Copy and paste a formatted citation
Spandidos Publications style
Ji C, Yang Y, Yang B, Xia J, Sun W, Su Z, Yu L, Shan S, He S, Cheng L, Cheng L, et al: Trans-Zeatin attenuates ultraviolet induced down-regulation of aquaporin-3 in cultured human skin keratinocytes . Int J Mol Med 26: 257-263, 2010.
APA
Ji, C., Yang, Y., Yang, B., Xia, J., Sun, W., Su, Z. ... Bi, Z. (2010). Trans-Zeatin attenuates ultraviolet induced down-regulation of aquaporin-3 in cultured human skin keratinocytes . International Journal of Molecular Medicine, 26, 257-263. https://doi.org/10.3892/ijmm_00000460
MLA
Ji, C., Yang, Y., Yang, B., Xia, J., Sun, W., Su, Z., Yu, L., Shan, S., He, S., Cheng, L., Wan, Y., Bi, Z."Trans-Zeatin attenuates ultraviolet induced down-regulation of aquaporin-3 in cultured human skin keratinocytes ". International Journal of Molecular Medicine 26.2 (2010): 257-263.
Chicago
Ji, C., Yang, Y., Yang, B., Xia, J., Sun, W., Su, Z., Yu, L., Shan, S., He, S., Cheng, L., Wan, Y., Bi, Z."Trans-Zeatin attenuates ultraviolet induced down-regulation of aquaporin-3 in cultured human skin keratinocytes ". International Journal of Molecular Medicine 26, no. 2 (2010): 257-263. https://doi.org/10.3892/ijmm_00000460
Copy and paste a formatted citation
x
Spandidos Publications style
Ji C, Yang Y, Yang B, Xia J, Sun W, Su Z, Yu L, Shan S, He S, Cheng L, Cheng L, et al: Trans-Zeatin attenuates ultraviolet induced down-regulation of aquaporin-3 in cultured human skin keratinocytes . Int J Mol Med 26: 257-263, 2010.
APA
Ji, C., Yang, Y., Yang, B., Xia, J., Sun, W., Su, Z. ... Bi, Z. (2010). Trans-Zeatin attenuates ultraviolet induced down-regulation of aquaporin-3 in cultured human skin keratinocytes . International Journal of Molecular Medicine, 26, 257-263. https://doi.org/10.3892/ijmm_00000460
MLA
Ji, C., Yang, Y., Yang, B., Xia, J., Sun, W., Su, Z., Yu, L., Shan, S., He, S., Cheng, L., Wan, Y., Bi, Z."Trans-Zeatin attenuates ultraviolet induced down-regulation of aquaporin-3 in cultured human skin keratinocytes ". International Journal of Molecular Medicine 26.2 (2010): 257-263.
Chicago
Ji, C., Yang, Y., Yang, B., Xia, J., Sun, W., Su, Z., Yu, L., Shan, S., He, S., Cheng, L., Wan, Y., Bi, Z."Trans-Zeatin attenuates ultraviolet induced down-regulation of aquaporin-3 in cultured human skin keratinocytes ". International Journal of Molecular Medicine 26, no. 2 (2010): 257-263. https://doi.org/10.3892/ijmm_00000460
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