Anti-asthmatic activities in mycelial extract and culture filtrate of Cordyceps sphecocephala J201

  • Authors:
    • Jin-Chul Heo
    • Sung-Hee Nam
    • Dong-Yoon Nam
    • Jong-Guk Kim
    • Kwang-Gil Lee
    • Joo-Hong Yeo
    • Cheol-Sik Yoon
    • Chul-Hong Park
    • Sang-Han Lee
  • View Affiliations

  • Published online on: September 1, 2010     https://doi.org/10.3892/ijmm_00000472
  • Pages: 351-356
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Abstract

This study investigated the effects of mycelial extract and culture filtrate of Cordyceps sphecocephala J201 on airway hyper-responsiveness, pulmonary immune cell infiltration, and Th2 cytokine expression in animal models of asthma. After Concanavalin A (Con A) activation of mouse primary spleen cells, the IL-4 and IL-13 cytokine expression were significantly decreased in the presence of the mycelial extract and culture filtrate of Cordyceps sphecocephala J201. The asthma model was induced by sensitization to ovalbumin by intraperitoneal (i.p.) injection treatment in mice. The Cordyceps sphecocephala J201 mycelial extract was injected in order to assess the effects of anti-asthmatic activity by comparing lung cell infiltration in ovalbumin-induced asthmatic mice. The results revealed that the increased IL-4, IL-13 and IL-25 expression were controlled by the mycelial extract and culture filtrate of Cordyceps sphecocephala J201, indicating that the extracts reduced the undesirable immune responses and/or cytokine expression exhibited in asthma.

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September 2010
Volume 26 Issue 3

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Heo J, Nam S, Nam D, Kim J, Lee K, Yeo J, Yoon C, Park C and Lee S: Anti-asthmatic activities in mycelial extract and culture filtrate of Cordyceps sphecocephala J201 . Int J Mol Med 26: 351-356, 2010
APA
Heo, J., Nam, S., Nam, D., Kim, J., Lee, K., Yeo, J. ... Lee, S. (2010). Anti-asthmatic activities in mycelial extract and culture filtrate of Cordyceps sphecocephala J201 . International Journal of Molecular Medicine, 26, 351-356. https://doi.org/10.3892/ijmm_00000472
MLA
Heo, J., Nam, S., Nam, D., Kim, J., Lee, K., Yeo, J., Yoon, C., Park, C., Lee, S."Anti-asthmatic activities in mycelial extract and culture filtrate of Cordyceps sphecocephala J201 ". International Journal of Molecular Medicine 26.3 (2010): 351-356.
Chicago
Heo, J., Nam, S., Nam, D., Kim, J., Lee, K., Yeo, J., Yoon, C., Park, C., Lee, S."Anti-asthmatic activities in mycelial extract and culture filtrate of Cordyceps sphecocephala J201 ". International Journal of Molecular Medicine 26, no. 3 (2010): 351-356. https://doi.org/10.3892/ijmm_00000472