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ALVEOLAR RHABDOMYOSARCOMA - PRIMARY AND RECURRENT METASTATIC TUMOR HAS CHROMOSOMAL TRANSLOCATION T(2-13)(Q37-Q14), AMPLIFIED N-MYC AND IS TUMORIGENIC IN NUDE-MICE

  • Authors:
    • P DIAS
    • P KUMAR
    • HB MARSDEN
    • HR GATTAMANENI
    • J HEIGHWAY
    • S KUMAR

  • View Affiliations

  • Published online on: June 1, 1992     https://doi.org/10.3892/ijo.1.1.47
  • Pages: 47-51
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Abstract

Tissue specimens of primary and recurrent metastatic alveolar rhabdomyosarcoma (A-RMS) from a 12 year old child were cultured and shown to contain A-RMS specific t(2;13) (q37;q14) chromosomal translocation and to be tumourigenic in nude mice. Whereas c-myc protooncogene was neither amplified nor grossly rearranged, both biopsy samples were demonstrated to have 5-fold amplification of N-myc gene sequence. N-myc gene was also amplified in cell cultures produced by primary and metastatic tumour biopsies. Such a model for A-RMS has not been previously available.

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June 1992
Volume 1 Issue 1

Print ISSN: 1019-6439
Online ISSN:1791-2423

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  • Source Normalized Impact per Paper (SNIP): 1.125
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Spandidos Publications style
DIAS P, KUMAR P, MARSDEN H, GATTAMANENI H, HEIGHWAY J and KUMAR S: ALVEOLAR RHABDOMYOSARCOMA - PRIMARY AND RECURRENT METASTATIC TUMOR HAS CHROMOSOMAL TRANSLOCATION T(2-13)(Q37-Q14), AMPLIFIED N-MYC AND IS TUMORIGENIC IN NUDE-MICE. Int J Oncol 1: 47-51, 1992
APA
DIAS, P., KUMAR, P., MARSDEN, H., GATTAMANENI, H., HEIGHWAY, J., & KUMAR, S. (1992). ALVEOLAR RHABDOMYOSARCOMA - PRIMARY AND RECURRENT METASTATIC TUMOR HAS CHROMOSOMAL TRANSLOCATION T(2-13)(Q37-Q14), AMPLIFIED N-MYC AND IS TUMORIGENIC IN NUDE-MICE. International Journal of Oncology, 1, 47-51. https://doi.org/10.3892/ijo.1.1.47
MLA
DIAS, P., KUMAR, P., MARSDEN, H., GATTAMANENI, H., HEIGHWAY, J., KUMAR, S."ALVEOLAR RHABDOMYOSARCOMA - PRIMARY AND RECURRENT METASTATIC TUMOR HAS CHROMOSOMAL TRANSLOCATION T(2-13)(Q37-Q14), AMPLIFIED N-MYC AND IS TUMORIGENIC IN NUDE-MICE". International Journal of Oncology 1.1 (1992): 47-51.
Chicago
DIAS, P., KUMAR, P., MARSDEN, H., GATTAMANENI, H., HEIGHWAY, J., KUMAR, S."ALVEOLAR RHABDOMYOSARCOMA - PRIMARY AND RECURRENT METASTATIC TUMOR HAS CHROMOSOMAL TRANSLOCATION T(2-13)(Q37-Q14), AMPLIFIED N-MYC AND IS TUMORIGENIC IN NUDE-MICE". International Journal of Oncology 1, no. 1 (1992): 47-51. https://doi.org/10.3892/ijo.1.1.47