RAS AND P53 EXPRESSION IN NON-SMALL-CELL LUNG-CANCER PATIENTS - P53 OVER-EXPRESSION CORRELATES WITH A POOR PROGNOSIS

  • Authors:
    • E PAPADAKIS
    • A MALLIRI
    • S LINARDOPOULOS
    • H KARAIOSSIFIDI
    • JK FIELD
    • DA SPANDIDOS
  • View Affiliations

  • Published online on: September 1, 1992     https://doi.org/10.3892/ijo.1.4.403
  • Pages: 403-413
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Abstract

Expression of the tumor suppressor gene p53 and the ras oncogene were examined in 46 tumor and nodal specimens of non-small cell lung cancer (NSCLC) using the antibodies p53 pAb 240 and ras Y13-259 respectively. p53 expression was elevated in 46% and ras p21 was over-expressed in 85% of the tumor specimens analyzed. Fifteen cases of benign lessions were also assessed for both ras p21 and p53 expression; all were found to have negative staining. p53 over-expression was found to correlate with a poor prognosis in both the tumor specimens (p<0.05) and in the nodal tissues (p<0.005). Ras p21 over-expression was found to be associated with survival (p<0.1) in both the tumor and the nodal specimens. Stage of the disease correlated with survival; similarly both p53 and ras p21 over-expression correlated with stage. No correlations were found with the pathological grade of the tumors nor with a history of smoking or duration of smoking. No K-ras mutations at codon 12 were observed in a further 15 NSCLC specimens analyzed. These results indicate that the p53 gene in particular plays a role in the stages of NSCLC.

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September 1992
Volume 1 Issue 4

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
PAPADAKIS E, MALLIRI A, LINARDOPOULOS S, KARAIOSSIFIDI H, FIELD J and SPANDIDOS D: RAS AND P53 EXPRESSION IN NON-SMALL-CELL LUNG-CANCER PATIENTS - P53 OVER-EXPRESSION CORRELATES WITH A POOR PROGNOSIS. Int J Oncol 1: 403-413, 1992.
APA
PAPADAKIS, E., MALLIRI, A., LINARDOPOULOS, S., KARAIOSSIFIDI, H., FIELD, J., & SPANDIDOS, D. (1992). RAS AND P53 EXPRESSION IN NON-SMALL-CELL LUNG-CANCER PATIENTS - P53 OVER-EXPRESSION CORRELATES WITH A POOR PROGNOSIS. International Journal of Oncology, 1, 403-413. https://doi.org/10.3892/ijo.1.4.403
MLA
PAPADAKIS, E., MALLIRI, A., LINARDOPOULOS, S., KARAIOSSIFIDI, H., FIELD, J., SPANDIDOS, D."RAS AND P53 EXPRESSION IN NON-SMALL-CELL LUNG-CANCER PATIENTS - P53 OVER-EXPRESSION CORRELATES WITH A POOR PROGNOSIS". International Journal of Oncology 1.4 (1992): 403-413.
Chicago
PAPADAKIS, E., MALLIRI, A., LINARDOPOULOS, S., KARAIOSSIFIDI, H., FIELD, J., SPANDIDOS, D."RAS AND P53 EXPRESSION IN NON-SMALL-CELL LUNG-CANCER PATIENTS - P53 OVER-EXPRESSION CORRELATES WITH A POOR PROGNOSIS". International Journal of Oncology 1, no. 4 (1992): 403-413. https://doi.org/10.3892/ijo.1.4.403