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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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October 1992 Volume 1 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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October 1992 Volume 1 Issue 5

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Article

PHOSPHORYLATION OF WILD-TYPE AND MUTANT PHENOTYPES OF P53 BY AN ASSOCIATED PROTEIN-KINASE

  • Authors:
    • A LORENZ
    • CPE HERRMANN
    • OG ISSINGER
    • M MONTENARH

  • View Affiliations / Copyright

    Affiliations: UNIV SAARLAND,GEBAUDE 44,W-6650 HOMBURG,GERMANY. UNIV SAARLAND,INST HUMAN GENET,W-6650 HOMBURG,GERMANY.
  • Pages: 571-579
    |
    Published online on: October 1, 1992
       https://doi.org/10.3892/ijo.1.5.571
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Abstract

Immunopurified mutant mouse p53 from transformed cells is known to be tightly associated with a protein kinase which phosphorylates p53 in an in vitro kinase reaction. Wild-type p53 from a non-transformed cell line was not associated with a protein kinase whereas immunopurified wild-type p53 from a transformed cell line was tightly associated with a protein kinase which phosphorylated p53. In order to compare wild-type and mutant p53 in the same cellular environment both forms were cloned in a baculovirus expression system and in in vitro transcription/translation vectors and both p53 proteins were expressed in the two systems. Wild-type and mutant p53 from baculovirus infected insect cells were tightly associated with a protein kinase which phosphorylates p53. In contrast, immunopurified wild-type and mutant p53 from an in vitro transcription/translation reaction were not associated with a protein kinase but could be phosphorylated by added casein kinase II. Thus, in the present paper we demonstrate that the association of p53 with a protein kinase and the in vitro phosphorylation of p53 seems to depend on the surrounding cellular environment.

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Copy and paste a formatted citation
Spandidos Publications style
LORENZ A, HERRMANN C, ISSINGER O and MONTENARH M: PHOSPHORYLATION OF WILD-TYPE AND MUTANT PHENOTYPES OF P53 BY AN ASSOCIATED PROTEIN-KINASE. Int J Oncol 1: 571-579, 1992.
APA
LORENZ, A., HERRMANN, C., ISSINGER, O., & MONTENARH, M. (1992). PHOSPHORYLATION OF WILD-TYPE AND MUTANT PHENOTYPES OF P53 BY AN ASSOCIATED PROTEIN-KINASE. International Journal of Oncology, 1, 571-579. https://doi.org/10.3892/ijo.1.5.571
MLA
LORENZ, A., HERRMANN, C., ISSINGER, O., MONTENARH, M."PHOSPHORYLATION OF WILD-TYPE AND MUTANT PHENOTYPES OF P53 BY AN ASSOCIATED PROTEIN-KINASE". International Journal of Oncology 1.5 (1992): 571-579.
Chicago
LORENZ, A., HERRMANN, C., ISSINGER, O., MONTENARH, M."PHOSPHORYLATION OF WILD-TYPE AND MUTANT PHENOTYPES OF P53 BY AN ASSOCIATED PROTEIN-KINASE". International Journal of Oncology 1, no. 5 (1992): 571-579. https://doi.org/10.3892/ijo.1.5.571
Copy and paste a formatted citation
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Spandidos Publications style
LORENZ A, HERRMANN C, ISSINGER O and MONTENARH M: PHOSPHORYLATION OF WILD-TYPE AND MUTANT PHENOTYPES OF P53 BY AN ASSOCIATED PROTEIN-KINASE. Int J Oncol 1: 571-579, 1992.
APA
LORENZ, A., HERRMANN, C., ISSINGER, O., & MONTENARH, M. (1992). PHOSPHORYLATION OF WILD-TYPE AND MUTANT PHENOTYPES OF P53 BY AN ASSOCIATED PROTEIN-KINASE. International Journal of Oncology, 1, 571-579. https://doi.org/10.3892/ijo.1.5.571
MLA
LORENZ, A., HERRMANN, C., ISSINGER, O., MONTENARH, M."PHOSPHORYLATION OF WILD-TYPE AND MUTANT PHENOTYPES OF P53 BY AN ASSOCIATED PROTEIN-KINASE". International Journal of Oncology 1.5 (1992): 571-579.
Chicago
LORENZ, A., HERRMANN, C., ISSINGER, O., MONTENARH, M."PHOSPHORYLATION OF WILD-TYPE AND MUTANT PHENOTYPES OF P53 BY AN ASSOCIATED PROTEIN-KINASE". International Journal of Oncology 1, no. 5 (1992): 571-579. https://doi.org/10.3892/ijo.1.5.571
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